POLI and NEDD8

Number of citations of the paper that reports this interaction (PubMedID 30659753)
3

Data Source:
BioGRID (unspecified method)

		POLI	NEDD8
Description		DNA polymerase iota	NEDD8 ubiquitin like modifier
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GO Annotations	Cellular Component	Intracellular Nucleoplasm Nuclear Speck Cytoplasmic Ribonucleoprotein Granule	Cell Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Damaged DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Metal Ion Binding	Protein Binding Protein Tag Ubiquitin Protein Ligase Binding
	Biological Process	DNA Replication DNA Repair Translesion Synthesis Error-prone Translesion Synthesis	Regulation Of Transcription By RNA Polymerase II Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Cellular Iron Ion Homeostasis Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Ubiquitination Protein Deubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Post-translational Protein Modification Protein Neddylation
Pathways		Translesion synthesis by POLI Termination of translesion DNA synthesis	TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport
Drugs
Diseases
GWAS		Asthma ( 31361310 30929738) Asthma (childhood onset) ( 30929738) Inflammatory skin disease ( 25574825)	Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		20 interacting genes: APP CALCOCO2 DAZAP2 DVL2 EP300 MFHAS1 MTNR1B NEDD8 PCNA POLH REV1 RNF11 TMEM239 TRAF6 TRIM23 TRIM39 UBA52 UBB UBC ZBTB44	42 interacting genes: AHR ARIH2 ATE1 ATXN3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNMT3B GARS1 GHR HGS HIF1A N4BP1 NAE1 NUB1 OTUB1 OTUD5 PARP1 POLI PSMA6 PSMD4 PTK2 RAD23A SENP8 SMURF1 TP53 UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2
Entrez ID		11201	4738
HPRD ID		16094	04412
Ensembl ID		ENSG00000101751	ENSG00000129559
Uniprot IDs		Q9UNA4	Q15843
PDB IDs		1T3N 1ZET 2ALZ 2DPI 2DPJ 2FLL 2FLN 2FLP 2KHU 2KHW 2KTF 2L0F 2L0G 2MBB 3EPG 3EPI 3G6V 3G6X 3G6Y 3GV5 3GV7 3GV8 3H40 3H4B 3H4D 3NGD 3OSN 3Q8P 3Q8Q 3Q8R 3Q8S 4EBC 4EBD 4EBE 4EYH 4EYI 4FS1 4FS2 5KT2 5KT3 5KT4 5KT5 5KT6 5KT7 5ULW 5ULX	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F
Enriched GO Terms of Interacting Partners?
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