LZTS1 and CDC25C

Number of citations of the paper that reports this interaction (PubMedID 17349584)
27

Data Source:
HPRD (in vitro, in vivo)

		LZTS1	CDC25C
Description		leucine zipper tumor suppressor 1	cell division cycle 25C
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Density Apical Plasma Membrane Cell Junction Dendritic Spine Dendritic Shaft Cell Body Postsynaptic Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Protein Binding Microtubule Binding	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding WW Domain Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Negative Regulation Of Macroautophagy Mitotic Cell Cycle Phase Transition Regulation Of Synaptic Plasticity Regulation Of Dendrite Morphogenesis	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G2/M Transition Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Regulation Of Mitotic Nuclear Division Cell Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Peptidyl-tyrosine Dephosphorylation Positive Regulation Of Mitotic Cell Cycle Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle
Pathways			Polo-like kinase mediated events Activation of ATR in response to replication stress RHO GTPases activate PKNs TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Cyclin A/B1/B2 associated events during G2/M transition Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs
Diseases
GWAS		Circulating myeloperoxidase levels (serum) ( 23620142) Dental caries ( 23064961 23259602) Influenza A (H1N1) infection ( 26379185) Major depressive disorder (broad) ( 20038947) Preeclampsia ( 23551011) Rheumatoid arthritis ( 30891314) Severe influenza A (H1N1) infection ( 26379185) Susceptibility to persistent hepatitis B virus infection ( 27244555)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Intraocular pressure ( 31959993) Normal facial asymmetry (deformation magnitude) ( 30631343) Response to radiotherapy in prostate cancer (toxicity, urinary frequency) ( 27515689) Schizophrenia ( 25056061)
Interacting Genes		4 interacting genes: CDC25C CDK1 EEF1G HMGB2	35 interacting genes: BRCA1 BRSK1 BRSK2 CCNA2 CCNB1 CDK1 CDK2 CDK5 CDS1 CHEK1 CHEK2 ERBB3 ERBB4 FHL1 HRAS LCK LMTK2 LZTS1 MAPK1 MAPK14 MAPK3 MAPK9 MARK3 NEDD4 PCNA PIN1 PKN1 PLK1 PLK3 ROR2 TP53 YWHAB YWHAH YWHAQ YWHAZ
Entrez ID		11178	995
HPRD ID		05945	01146
Ensembl ID		ENSG00000061337	ENSG00000158402
Uniprot IDs		Q9Y250	B4DX61 P30307
PDB IDs			2OJX 3BZI 3OP3 5M35 5M36 5M37
Enriched GO Terms of Interacting Partners?
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