CD160 and MDM4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CD160	MDM4
Description		CD160 molecule	MDM4 regulator of p53
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Anchored Component Of Plasma Membrane	Nucleus Nucleoplasm
	Molecular Function	Signaling Receptor Binding Protein Binding Kinase Binding MHC Class I Protein Complex Binding MHC Class I Receptor Activity MHC Class Ib Receptor Activity Activating MHC Class I Receptor Activity	Protein Binding Zinc Ion Binding Enzyme Binding
	Biological Process	Angiogenesis Adaptive Immune Response Mucosal Immune Response Positive Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Angiogenesis T Cell Costimulation Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Defense Response To Gram-negative Bacterium Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of CD4-positive, Alpha-beta T Cell Costimulation Positive Regulation Of Interferon-gamma Secretion Negative Regulation Of Adaptive Immune Memory Response Positive Regulation Of Endothelial Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Valve Development Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Ventricular Septum Development Atrial Septum Development DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Cell Proliferation Protein Deubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Protein Stabilization Protein-containing Complex Assembly Negative Regulation Of Cell Cycle Arrest Cellular Response To Hypoxia Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Oxidative Stress Induced Senescence Oncogene Induced Senescence Ub-specific processing proteases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation Stabilization of p53
Drugs
Diseases
GWAS		Diastolic blood pressure ( 30224653)	Breast cancer ( 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915) Breast Cancer in BRCA1 mutation carriers ( 23544013) Cognitive performance ( 19734545) Diastolic blood pressure ( 27618452 30578418) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Glioma ( 28346443) Non-glioblastoma glioma ( 28346443) Prostate cancer ( 23535732) Regular attendance at a religious group ( 29970889) Systolic blood pressure ( 27618452)
Interacting Genes		3 interacting genes: AGTRAP MDM4 TNFRSF14	58 interacting genes: AKT1 APP ARF1 ATM BECN1 CAPN7 CASP3 CBLC CD160 CD44 CDK1 CDK4 CDKN2A CDKN2B CHEK1 CHEK2 CSNK1A1 E2F1 EP300 EPHA2 FGFR4 GLIS2 HGF LATS2 LRSAM1 MAGEA1 MAP2K5 MDM2 MKRN3 MNAT1 NF2 PELI1 PRKAA1 RAD54B RB1 RNF115 S100B SFN SMAD3 SMAD4 SMARCA2 TP53 TP63 TP73 TRIM46 TRIM55 UBC UBE2D1 UBE2D2 UBE2D3 USP7 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ ZKSCAN4
Entrez ID		11126	4194
HPRD ID		06833	04082
Ensembl ID		ENSG00000117281	ENSG00000198625
Uniprot IDs		O95971 Q6FH89	A0A087WTR9 A0A087WUE3 A0A087WZ58 O15151 Q59FS6 Q68DC0
PDB IDs		6NG3 6NG9 6NGG	2CR8 2MWY 2N06 2N0U 2N0W 2N14 2VJE 2VJF 2VYR 3DAB 3EQY 3FDO 3FE7 3FEA 3JZO 3JZP 3JZQ 3LBJ 3MQR 3U15 4RXZ 5MNJ 5UML 5VK1 6Q9Q 6Q9S 6Q9U 6Q9W 6Q9Y
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?