DUSP14 and EPHA1

Number of citations of the paper that reports this interaction (PubMedID 28065597)
26

Data Source:
BioGRID (two hybrid)

		DUSP14	EPHA1
Description		dual specificity phosphatase 14	EPH receptor A1
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GO Annotations	Cellular Component		Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Dendritic Spine Receptor Complex
	Molecular Function	RNA Binding Protein Tyrosine Phosphatase Activity Protein Binding MAP Kinase Tyrosine/serine/threonine Phosphatase Activity	Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity ATP Binding Protein Kinase Binding
	Biological Process	Inactivation Of MAPK Activity Peptidyl-tyrosine Dephosphorylation	Angiogenesis Positive Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Positive Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Kinase Activity Substrate Adhesion-dependent Cell Spreading Somatic Stem Cell Population Maintenance Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Protein Autophosphorylation Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Activation Of GTPase Activity
Pathways			EPH-Ephrin signaling EPH-Ephrin signaling POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs
Diseases
GWAS		Monocyte count ( 27863252) Ovarian cancer ( 23535730) Platelet count ( 27863252) Plateletcrit ( 27863252)	Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576 29875488 28240269) Family history of Alzheimer's disease ( 30617256)
Interacting Genes		17 interacting genes: AATK CBY2 CD28 EPHA1 EPHA2 ERBB2 ERBB3 ERBB4 FGFR2 IGF1R ISYNA1 LMTK2 PRMT5 PTK7 ROR1 ROR2 UCHL5	12 interacting genes: CTDSP2 DAPK1 DUSP14 EFNA1 ERBB2 GJB1 MAP3K1 MTMR14 PTPN11 SMURF1 SMURF2 TPTE
Entrez ID		11072	2041
HPRD ID		09427	01554
Ensembl ID		ENSG00000276023	ENSG00000146904
Uniprot IDs		O95147 Q6FI36	P21709
PDB IDs		2WGP	2K1K 2K1L 3HIL 3KKA
Enriched GO Terms of Interacting Partners?
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