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UBE2C and RAG1
Number of citations of the paper that reports this interaction (PubMedID
12629039
)
32
Data Source:
BioGRID
(pull down)
UBE2C
RAG1
Description
ubiquitin conjugating enzyme E2 C
recombination activating 1
Image
No pdb structure
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Cell
Nucleus
Nucleoplasm
Anaphase-promoting Complex
Cytosol
Plasma Membrane
Nucleus
Nucleoplasm
DNA Recombinase Complex
Endodeoxyribonuclease Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin-like Protein Ligase Binding
Ubiquitin Conjugating Enzyme Activity
DNA Binding
Endonuclease Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Histone Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Double-stranded DNA Endodeoxyribonuclease Activity
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Exit From Mitosis
Free Ubiquitin Chain Polymerization
Protein Ubiquitination
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of Exit From Mitosis
Cell Division
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Adaptive Immune Response
Pre-B Cell Allelic Exclusion
DNA Recombination
Immune Response
Visual Learning
Histone Monoubiquitination
B Cell Differentiation
T Cell Differentiation In Thymus
V(D)J Recombination
T Cell Homeostasis
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of T Cell Differentiation
Thymus Development
Protein Autoubiquitination
Negative Regulation Of Thymocyte Apoptotic Process
Nucleic Acid Phosphodiester Bond Hydrolysis
Regulation Of Behavioral Fear Response
Pathways
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Interleukin-7 signaling
MAPK6/MAPK4 signaling
Drugs
Diseases
Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS
Height (
31562340
)
Rheumatoid arthritis (
24390342
)
Interacting Genes
29 interacting genes:
ANAPC11
ANAPC2
AURKA
CDC20
CKAP2
CXCR1
DTX1
ENO2
FBXO5
FZR1
GMNN
ITCH
KLHL2
MAPK7
PCGF3
POLM
PRKN
PSMD4
RAG1
RELA
RNF31
RNF7
TNNC1
TRIM21
TRIM28
TRIM29
UBA1
UBASH3B
UBE3D
18 interacting genes:
APP
DCAF1
H2AC20
H2BC21
H3-4
H3C1
H4-16
HMGB1
HMGB2
KPNA1
KPNA2
RAG2
TBCA
UBC
UBE2C
UBE2D1
UBE2D2
UBE2H
Entrez ID
11065
5896
HPRD ID
05717
01556
Ensembl ID
ENSG00000175063
ENSG00000166349
Uniprot IDs
A0A087WVK1
A0A0A0MSE8
O00762
Q5TZN3
P15918
PDB IDs
1I7K
4YII
5A31
5KHR
5L9U
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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