TMED10 and PSENEN

Number of citations of the paper that reports this interaction (PubMedID 16641999)
122

Data Source:
HPRD (in vivo)

		TMED10	PSENEN
Description		transmembrane p24 trafficking protein 10	presenilin enhancer, gamma-secretase subunit
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cell Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Cis-Golgi Network Plasma Membrane ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Transport Vesicle COPII-coated ER To Golgi Transport Vesicle COPI-coated Vesicle Trans-Golgi Network Transport Vesicle Secretory Granule Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome Zymogen Granule Membrane Gamma-secretase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Integral Component Of Membrane Golgi Cisterna Membrane Gamma-secretase Complex
	Molecular Function	Protein Binding Syntaxin Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Kidney Development Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Golgi Organization Cargo Loading Into Vesicle COPI-coated Vesicle Budding Response To Alkaloid Regulated Exocytosis Vesicle Targeting, To, From Or Within Golgi COPI Coating Of Golgi Vesicle COPII Vesicle Coating Regulation Of Amyloid-beta Formation	Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Amyloid-beta Formation Notch Receptor Processing, Ligand-dependent Amyloid Precursor Protein Metabolic Process Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3 Amyloid fiber formation
Drugs			E-2012
Diseases			Acne inversa; Hidradenitis supprativa
GWAS		Heel bone mineral density ( 30598549) Height ( 19343178)
Interacting Genes		18 interacting genes: APH1A ARCN1 ARF1 COPA COPB1 COPB2 COPE COPG1 COPG2 COPZ1 DHODH FBXO7 GORASP2 NCSTN NPC2 PSENEN SEC23B TMED2	7 interacting genes: APH1A CREB3 NCSTN PSEN1 PSEN2 THBD TMED10
Entrez ID		10972	55851
HPRD ID		12013	06362
Ensembl ID		ENSG00000170348	ENSG00000205155
Uniprot IDs		A0A024R6I3 P49755	Q9NZ42
PDB IDs			5A63 5FN2 5FN3 5FN4 5FN5 6IDF 6IYC
Enriched GO Terms of Interacting Partners?
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