COPS8 and COPS4

Number of citations of the paper that reports this interaction (PubMedID 11337588)
231

Data Source:
BioGRID (biochemical, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo)

		COPS8	COPS4
Description		COP9 signalosome subunit 8	COP9 signalosome subunit 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleus Nucleoplasm Cytosol Synaptic Vesicle COP9 Signalosome Nuclear Speck Cell Junction
	Molecular Function	Protein Binding	Protein Binding NEDD8-specific Protease Activity
	Biological Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Protein Phosphorylation Activation Of NF-kappaB-inducing Kinase Activity Negative Regulation Of Cell Proliferation COP9 Signalosome Assembly Post-translational Protein Modification	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Post-translational Protein Modification
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Asthma ( 27611488) Body mass index ( 25673413) Lung cancer ( 28604730) Motion sickness ( 25628336) Pulse pressure ( 27841878) Systemic lupus erythematosus ( 19838195)	Metabolite levels ( 23823483)
Interacting Genes		16 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 DDB1 EIF3E GPS1 ITPK1 MAPRE1 NFKBIA TP53 USHBP1	19 interacting genes: C19orf57 CCDC85B COPS2 COPS3 COPS5 COPS6 COPS7A COPS8 CUL5 FOS IKBKB IL1RN KRT19 MBIP RCBTB2 TP53 UBQLN1 USHBP1 YWHAQ
Entrez ID		10920	51138
HPRD ID		16737	09888
Ensembl ID		ENSG00000198612	ENSG00000138663
Uniprot IDs		A0A024R4D1 Q99627	A0A0S2Z5H7 B3KM48 D6RAX7 Q9BT78
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N	4D0P 4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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