CFTR and UBE2I

Number of citations of the paper that reports this interaction (PubMedID 26627832)
12

Data Source:
BioGRID (enzymatic study)

		CFTR	UBE2I
Description		CF transmembrane conductance regulator	ubiquitin conjugating enzyme E2 I
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GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Lysosomal Membrane Early Endosome Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Golgi-associated Vesicle Membrane Clathrin-coated Vesicle Membrane Early Endosome Membrane Protein-containing Complex Chloride Channel Complex Recycling Endosome Recycling Endosome Membrane	Synaptonemal Complex Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol PML Body Transferase Complex Sumoylated E2 Ligase Complex
	Molecular Function	Chloride Channel Activity Intracellularly ATP-gated Chloride Channel Activity Protein Binding ATP Binding Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Isomerase Activity ATPase Activity Chloride Channel Regulator Activity Chloride Channel Inhibitor Activity Enzyme Binding PDZ Domain Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Chaperone Binding Sec61 Translocon Complex Binding	RNA Binding Protein Binding ATP Binding Transcription Factor Binding SUMO Transferase Activity Enzyme Binding HLH Domain Binding Small Protein Activating Enzyme Binding SUMO Conjugating Enzyme Activity RING-like Zinc Finger Domain Binding
	Biological Process	Cholesterol Biosynthetic Process Vesicle Docking Involved In Exocytosis Bicarbonate Transport Protein Deubiquitination Cholesterol Transport Response To Endoplasmic Reticulum Stress Transepithelial Water Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Exocytosis Sperm Capacitation Multicellular Organismal Water Homeostasis Intracellular PH Elevation Transmembrane Transport Membrane Hyperpolarization Membrane Organization Cellular Response To CAMP Positive Regulation Of Cyclic Nucleotide-gated Ion Channel Activity Chloride Transmembrane Transport Positive Regulation Of Voltage-gated Chloride Channel Activity Cellular Response To Forskolin	Negative Regulation Of Transcription By RNA Polymerase II Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Cell Cycle Chromosome Segregation Viral Process Protein Sumoylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Cell Division Positive Regulation Of SUMO Transferase Activity
Pathways		ABC-family proteins mediated transport RHO GTPases regulate CFTR trafficking Defective CFTR causes cystic fibrosis Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy	Meiotic synapsis Vitamin D (calciferol) metabolism SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMOylation of DNA damage response and repair proteins SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation
Drugs		ATP Bumetanide Glyburide Ibuprofen Colforsin Phosphoaminophosphonic Acid-Adenylate Ester Dexfosfoserine Crofelemer Lonidamine Ivacaftor Dexibuprofen Lumacaftor
Diseases		Cystic fibrosis (CF) Hereditary pancreatitis; Hereditary chronic pancreatitis Congenital bilateral absence of vas deferens
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Glaucoma ( 30054594) Gout ( 22179738) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Idiopathic dilated cardiomyopathy ( 29495422) Pulse pressure ( 30224653 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		29 interacting genes: CANX CLCN3 DERL1 DNAJA1 DNAJC5 EZR GOPC HSP90AA1 MARCHF2 NHS PDZD3 PDZK1 PPP2R1B PRKAA1 PRKACA PRKAR2A PRKCA PRKCE PRKG1 RNF5 SLC4A7 SLC4A8 SLC9A3R1 SLC9A3R2 SLC9A6 SNAP23 STUB1 STX1A UBE2I	376 interacting genes: ADAR ADD3 AGTRAP ANAPC4 ANXA1 APEX1 APP AR ARHGDIA ARL13B ARNT ARNTL ATF2 ATF3 ATF7IP ATXN1 AURKA AURKB BCAM BCL11A BEND5 BHLHE40 BIRC3 BIRC7 BLM BLMH BMI1 C18orf25 CALU CAMSAP2 CARM1 CASP2 CASP8AP2 CBLC CBS CBX4 CCDC6 CD2AP CDC37 CDCA8 CDH4 CDKN1B CEBPD CEBPE CENPX CFTR CHD3 CHD4 CHFR CHMP1A CHMP4B CHUK CLDN2 CLK2 COG1 CORO2A CREB1 CREBBP CREM CSNK2B CTBP2 CTNNA1 DACH1 DAXX DDX21 DDX24 DDX39A DDX5 DES DHX9 DNM1 DNMT3A DNMT3B DPYSL2 DRG1 DTX3L DZIP3 EDARADD EDF1 EGR2 ELK1 EP300 ESR1 ETS1 ETV1 ETV6 EXO1 EXOSC9 FAF1 FANCM FAS FHIT FHL3 FLI1 FMR1 FOS FOXL2 FOXM1 GCM1 GLUL GMCL1 GMCL2 GMEB1 GMEB2 GOLGA2 GOLGB1 GRIP1 GTF2I H4-16 HABP4 HDAC1 HDAC4 HDAC5 HDAC7 HGS HIC1 HIF1A HIPK1 HIPK2 HIPK3 HIRA HMGB1 HMGN2 HNF4A HNRNPC HNRNPD HNRNPK HNRNPLL HNRNPM HNRNPU HSF1 HSF2 HSF2BP IKBKG IKZF1 IKZF3 IKZF5 IPO13 IQGAP1 JUN KAT2A KAT6B KCNA5 KCNK1 KCTD1 KDM1A KHSRP KLF3 KLF5 KLHL12 KMT5A KRT19 LATS1 LMNA LMO2 LNX2 MAP2K1 MAP3K1 MAPK1IP1L MARCHF5 MAT2A MATR3 MDM2 MECOM MED7 MEF2C MGRN1 MITF MKRN3 MRTFA MTA1 MYB MYBBP1A MYH9 NACC1 NAT10 NCOR2 NFKBIA NIN NMI NOL6 NONO NOP2 NOP56 NOP58 NOX5 NR1D2 NR1H2 NR1H3 NR1I2 NR3C1 NR3C2 NR5A1 NR5A2 NSD3 NUDCD3 NVL PARK7 PARP1 PDLIM7 PDZK1 PELI1 PEX10 PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PIM1 PLAAT4 PLAGL1 PML PPARA PPARG PPARGC1A PPM1J PRKAA2 PRKDC PRPF40A PRPF8 PSMC3 PSME3 PTEN PUF60 RAD18 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RB1 RBBP5 RBBP6 RBM14 RBM25 RC3H2 RCBTB2 RFPL3 RHOXF2 RIPK2 RNF10 RNF111 RNF115 RNF128 RNF133 RNF144B RNF185 RNF4 RNF40 RORB RPL11 RPL7 RPL8 RPS3A RPS6KA6 RWDD3 RXRA SAE1 SALL1 SART1 SATB1 SCNN1A SEMA6A SETBP1 SETDB1 SETX SFPQ SH3KBP1 SIAH1 SIAH2 SIRT1 SKIL SLC2A1 SLC2A4 SLX4 SMAD4 SNAI2 SND1 SNIP1 SNRNP200 SOCS6 SOX10 SOX4 SOX6 SOX9 SP100 SP3 SPECC1L SPOP SREBF1 SREBF2 SRF SSRP1 STAT1 STMN2 SUMO1 SUMO1P1 SUMO2 SUMO3 SUPT7L SUZ12 SYMPK TAB2 TAF1 TAF10 TAF12 TAF5 TBL1X TBL1XR1 TBP TCERG1 TCF3 TCF4 TDG TDP2 TERF2 TFAP2A TFAP2B TFAP2C TFCP2 THRA THRB TNFRSF1A TOP1 TOP2A TOP2B TOPORS TP53 TP63 TP73 TRAF3 TRAF4 TRAF6 TRIM21 TRIM23 TRIM24 TRIM27 TRIM28 TRIM29 TRIM38 TRIM41 TRIM54 TRIM63 TRIM72 TRIP13 TRPS1 TSHZ2 TSNAX UBA2 UBXN1 UCHL1 UNC119 USP25 VHL WNK1 WT1 WWP2 XBP1 XIAP XRCC1 XRCC5 ZBED1 ZBTB1 ZBTB16 ZBTB26 ZBTB7A ZBTB8A ZCCHC7 ZEB2 ZMYM2 ZNF106 ZNF24 ZNF451 ZNF646 ZNRD1
Entrez ID		1080	7329
HPRD ID		03883	09045
Ensembl ID		ENSG00000001626	ENSG00000103275
Uniprot IDs		A0A024R730 P13569	A8K503 B0QYN7 P63279
PDB IDs		1NBD 1XMI 1XMJ 2BBO 2BBS 2BBT 2LOB 2PZE 2PZF 2PZG 3GD7 3ISW 4WZ6 5D2D 5D3E 5D3F 5TF7 5TF8 5TFA 5TFB 5TFC 5TFD 5TFF 5TFG 5TFI 5TFJ 5TGK 5UAK 6HEP 6MSM 6O1V 6O2P	1A3S 1KPS 1Z5Q 1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2O25 2PE6 2PX9 2XWU 3A4S 3UIN 3UIO 3UIP 4W5V 4Y1L 5D2M 5F6D 5F6E 5F6U 5F6V 5F6W 5F6X 5F6Y 5FQ2
Enriched GO Terms of Interacting Partners?
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