CFL2 and LIMK1

Number of citations of the paper that reports this interaction (PubMedID 9655398)
380

Data Source:
HPRD (in vivo, in vitro)

		CFL2	LIMK1
Description		cofilin 2	LIM domain kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cell Actin Cytoskeleton Nuclear Matrix Z Disc I Band Extracellular Exosome	Nucleus Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Nuclear Speck Lamellipodium Neuron Projection
	Molecular Function	Protein Binding Actin Filament Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Heat Shock Protein Binding Metal Ion Binding
	Biological Process	Skeletal Muscle Tissue Development Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Sarcomere Organization Muscle Cell Cellular Homeostasis	Protein Phosphorylation Signal Transduction Rho Protein Signal Transduction Nervous System Development Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Bundle Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Axon Extension Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Stress Fiber Assembly
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion Sema3A PAK dependent Axon repulsion Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs RHO GTPases activate PAKs
Drugs			Dabrafenib
Diseases		Nemaline myopathy
GWAS		Atrial fibrillation ( 30061737 29892015) Hip circumference adjusted for BMI ( 28552196)	Pulse pressure ( 30224653) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		10 interacting genes: ACTB ACTG1 CAP2 CFL1 DSTN LIMK1 POT1 SSH1 STK11 ZYG11B	29 interacting genes: ABCA1 APP ARRB1 ARRB2 BMPR2 CDC42BPA CDKN1C CFL1 CFL2 FBXO7 H1-1 LATS1 LIMK2 MAPK14 MAPKAPK2 MBP MFHAS1 NRG1 PAK1 PAK2 PAK4 PAK6 PXN RLIM ROCK1 SELENOS SRPK1 SSH3 YWHAZ
Entrez ID		1073	3984
HPRD ID		03262	03210
Ensembl ID		ENSG00000165410	ENSG00000106683
Uniprot IDs		Q549N0 Q9Y281	P53667
PDB IDs			3S95 5HVJ 5HVK 5L6W 5NXC
Enriched GO Terms of Interacting Partners?
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