TNFSF13B and TNFRSF13B

Number of citations of the paper that reports this interaction (PubMedID 10801128)
246

Data Source:
HPRD (in vitro, in vivo)

		TNFSF13B	TNFRSF13B
Description		TNF superfamily member 13b	TNF receptor superfamily member 13B
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Protein Binding Signaling Receptor Activity
	Biological Process	B Cell Homeostasis Positive Regulation Of Germinal Center Formation Immune Response Signal Transduction Positive Regulation Of B Cell Proliferation T Cell Costimulation B Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Immunoglobulin Secretion	B Cell Homeostasis Hematopoietic Progenitor Cell Differentiation Adaptive Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TNFs bind their physiological receptors
Drugs		1,4-Diethylene Dioxide Citric Acid Belimumab
Diseases			Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Blood protein levels ( 30072576) IgG levels ( 28628107) Metabolite levels ( 23823483) Myeloid white cell count ( 27863252) Non-albumin protein levels ( 29403010) Platelet count ( 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Tonsillectomy ( 27182965 28928442) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count ( 27863252)	Albumin-globulin ratio ( 29403010) Diabetic retinopathy ( 21441570) Granulocyte percentage of myeloid white cells ( 27863252) Hematological and biochemical traits ( 20139978) Hematology traits ( 23303382) IgG levels ( 22673310) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Lymphocyte counts ( 27863252) Monoclonal gammopathy of undetermined significance ( 30737484) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Multiple myeloma ( 26007630 23955597) Multiple myeloma and monoclonal gammopathy ( 26007630) Non-albumin protein levels ( 22558069 29403010) Platelet count ( 27863252) Plateletcrit ( 27863252) Serum albumin level ( 29403010) Serum total protein level ( 23022100 29403010) Sodium levels ( 29403010) Tonsillectomy ( 27182965 28928442)
Interacting Genes		5 interacting genes: APP TNFRSF13B TNFRSF13C TNFRSF17 TNFSF13	7 interacting genes: CAMLG SGTA TNFSF13 TNFSF13B TRAF2 TRAF5 TRAF6
Entrez ID		10673	23495
HPRD ID		04914	05365
Ensembl ID		ENSG00000102524	ENSG00000240505
Uniprot IDs		A0A0U5J7Q1 Q9Y275	O14836 Q4ACX1
PDB IDs		1JH5 1KD7 1KXG 1OQD 1OQE 1OSG 3V56 4V46 4ZCH 5Y9J 6FXN	1XU1 1XUT
Enriched GO Terms of Interacting Partners?
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