CAMKK2 and CAMK4

Number of citations of the paper that reports this interaction (PubMedID 9822657)
73

Data Source:
HPRD (in vitro)

		CAMKK2	CAMK4
Description		calcium/calmodulin dependent protein kinase kinase 2	calcium/calmodulin dependent protein kinase IV
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Neuron Projection	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Calmodulin Binding ATP Binding	Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling Cellular Response To Reactive Oxygen Species Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation CAMKK-AMPK Signaling Cascade Positive Regulation Of Autophagy Of Mitochondrion	Adaptive Immune Response Myeloid Dendritic Cell Cytokine Production Protein Phosphorylation Inflammatory Response Signal Transduction Long-term Memory Peptidyl-serine Phosphorylation Regulation Of T Cell Differentiation In Thymus Intracellular Signal Transduction Myeloid Dendritic Cell Differentiation Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation
Pathways		CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Transcriptional activation of mitochondrial biogenesis CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Negative regulation of NMDA receptor-mediated neuronal transmission
Drugs			5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one
Diseases
GWAS		Left ventricular obstructive tract defect (inherited effect) ( 28468790) Type 2 diabetes ( 29358691)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184) Allergic sensitization ( 23817571) Allergy ( 27182965) Alzheimer's disease (cognitive decline) ( 23535033) Asthma ( 30929738 31619474) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood pressure ( 17903302) Medication use (thyroid preparations) ( 31015401) Periodontitis (PAL4Q3) ( 24024966) Self-reported allergy ( 23817569)
Interacting Genes		7 interacting genes: APP CALM1 CAMK1 CAMK4 CEP63 NEDD4 PRKACA	10 interacting genes: CABIN1 CAMKK1 CAMKK2 CREBBP GAPDH HDAC4 NEDD4 NOS1 NOTCH1 RELA
Entrez ID		10645	814
HPRD ID		06467	07169
Ensembl ID		ENSG00000110931	ENSG00000152495
Uniprot IDs		A0A024RBP6 A0A024RBP8 A0A024RBQ0 A0A024RBQ3 Q96RR4	Q16566
PDB IDs		2ZV2 5UY6 5UYJ 5VT1 5YV8 5YV9 5YVA 5YVB 5YVC 6BKU 6BLE 6BQL 6BQP 6BQQ 6BRC 6CMJ 6EWW 6FEL	2W4O
Enriched GO Terms of Interacting Partners?
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