STAMBP and SPG7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		STAMBP	SPG7
Description		STAM binding protein	SPG7 matrix AAA peptidase subunit, paraplegin
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Cleavage Furrow Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane M-AAA Complex Mitochondrial Permeability Transition Pore Complex Axon Cytoplasm
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Protein Domain Specific Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity	Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Zinc Ion Binding Unfolded Protein Binding
	Biological Process	Mitotic Cytokinesis JAK-STAT Cascade Positive Regulation Of Cell Proliferation Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Protein Deubiquitination Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Ras Protein Signal Transduction Protein K63-linked Deubiquitination	Proteolysis Mitochondrial Calcium Ion Transmembrane Transport Mitochondrion Organization Nervous System Development Anterograde Axonal Transport Regulation Of Mitochondrial Membrane Permeability Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
Pathways		Metalloprotease DUBs	Processing of SMDT1
Drugs
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Anti-saccade response ( 29064472) Blood metabolite levels ( 26401656) Serum metabolite levels ( 23093944)	Hair morphology traits ( 30166351) Heel bone mineral density ( 30598549) Type 2 diabetes ( 30297969) White coat effect (clinic systolic blood pressure minus ambulatory systolic blood pressure) ( 31044621)
Interacting Genes		43 interacting genes: ALAS1 AMN BMPR1B CASR CHMP1A CHMP1B CHMP2A CHMP3 CHMP4A CHMP4B CHMP4C CHMP5 CLTC CTNNBL1 CYP2C9 EPS15 GRAP2 GRB2 IL1RL2 ITGA5 MAP2K5 MAP3K2 NLRP7 NTPCR PJA1 RECQL5 RNF11 SMAD2 SMAD6 SMAD7 SNCA SPG7 STAM STAM2 TNFRSF1A TP53 TRAF6 TRIP13 UACA UBC UBE2S USP21 USP28	25 interacting genes: CCNDBP1 HNRNPK KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 KRTAP5-9 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NOTCH2NLA PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SASH1 SPATS1 STAMBP TRIM28
Entrez ID		10617	6687
HPRD ID		05877	04149
Ensembl ID		ENSG00000124356	ENSG00000197912
Uniprot IDs		A0A140VK54 O95630	A0A2R8Y632 Q9UQ90
PDB IDs		2XZE 3RZU 3RZV 5IXF	2QZ4
Enriched GO Terms of Interacting Partners?
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