SEC23A and SEC16A

Number of citations of the paper that reports this interaction (PubMedID 26496610)
285

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid, in vivo)

		SEC23A	SEC16A
Description		Sec23 homolog A, COPII coat complex component	SEC16 homolog A, endoplasmic reticulum export factor
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Extrinsic Component Of Membrane COPII Vesicle Coat Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Organelle Membrane Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding	Protein Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of GTPase Activity COPII Vesicle Coating Protein Localization To Plasma Membrane Cargo Loading Into COPII-coated Vesicle	ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Golgi Organization Substantia Nigra Development Protein Exit From Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress Golgi To Plasma Membrane CFTR Protein Transport COPII Vesicle Coating Protein Stabilization Positive Regulation Of Protein Exit From Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Exit Site Protein Localization To Plasma Membrane
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Antigen Presentation: Folding, assembly and peptide loading of class I MHC	COPII-mediated vesicle transport
Drugs
Diseases		Cranio-lenticulo-sutural dysplasia (CLSD); Boyadjiev-Jabs syndrome
GWAS		Metabolite levels ( 23823483) Vitamin D levels ( 29343764)	Basal cell carcinoma ( 31174203) Crohn's disease ( 28067908) Cutaneous squamous cell carcinoma ( 27424798) Eosinophil counts ( 27863252) Height ( 28552196) Inflammatory bowel disease ( 28067908) Squamous cell carcinoma ( 31174203) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		11 interacting genes: CDK16 CDK18 DCTN1 GLRA2 MIA2 MIA3 NDRG1 SDCBP2 SEC16A SEC24B SEC24C	2 interacting genes: MIA3 SEC23A
Entrez ID		10484	9919
HPRD ID		06714	11075
Ensembl ID		ENSG00000100934	ENSG00000148396
Uniprot IDs		Q15436	F1T0I1 O15027
PDB IDs		2NUP 2NUT 2YRC 2YRD 3EFO 3EG9 3EGD 3EGX 5KYN 5KYU 5KYW 5KYX 5KYY 5VNE 5VNF 5VNG 5VNH 5VNI 5VNJ 5VNK 5VNL 5VNM 5VNN 5VNO
Enriched GO Terms of Interacting Partners?
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