MERTK and GAS6

Number of citations of the paper that reports this interaction (PubMedID 8939948)
149

Data Source:
HPRD (in vitro)

		MERTK	GAS6
Description		MER proto-oncogene, tyrosine kinase	growth arrest specific 6
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Rhabdomere Receptor Complex	Extracellular Region Extracellular Space Cell Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Platelet Alpha Granule Lumen Extracellular Exosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Phosphatidylserine Binding Signaling Receptor Binding Calcium Ion Binding Protein Binding Protein Tyrosine Kinase Activator Activity Protein Binding, Bridging Receptor Tyrosine Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Receptor Ligand Activity
	Biological Process	Natural Killer Cell Differentiation Negative Regulation Of Cytokine Production Protein Phosphorylation Phagocytosis Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Multicellular Organism Development Spermatogenesis Nervous System Development Cell Migration Peptidyl-tyrosine Phosphorylation Platelet Activation Secretion By Cell Positive Regulation Of Kinase Activity Substrate Adhesion-dependent Cell Spreading Apoptotic Cell Clearance Protein Kinase B Signaling Positive Regulation Of Phagocytosis Leukocyte Migration Negative Regulation Of Lymphocyte Activation Retina Development In Camera-type Eye Vagina Development Neutrophil Clearance Negative Regulation Of Leukocyte Apoptotic Process	Neuron Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Platelet Degranulation Positive Regulation Of Glomerular Filtration Protein Phosphorylation ER To Golgi Vesicle-mediated Transport Phagocytosis Apoptotic Process Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Cellular Response To Starvation Positive Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Macrophage Cytokine Production Peptidyl-serine Phosphorylation Fusion Of Virus Membrane With Host Plasma Membrane Viral Genome Replication Animal Organ Regeneration Cell-substrate Adhesion Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-alpha Cellular Response To Drug B Cell Chemotaxis Regulation Of Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Apoptotic Cell Clearance Negative Regulation Of DNA-binding Transcription Factor Activity Protein Kinase B Signaling Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Fibroblast Proliferation Negative Regulation Of Interleukin-1 Secretion Positive Regulation Of Phagocytosis Leukocyte Migration Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Cellular Response To Vitamin K Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Protein Localization To Plasma Membrane Extracellular Matrix Assembly Dendritic Cell Differentiation Hematopoietic Stem Cell Migration To Bone Marrow Negative Regulation Of Oligodendrocyte Apoptotic Process Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of Renal Albumin Absorption Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Cell surface interactions at the vascular wall	Platelet degranulation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE
Diseases		Retinitis pigmentosa (RP)
GWAS		Coronary artery disease ( 29212778) Heel bone mineral density ( 30598549) Hepatitis C induced liver fibrosis ( 22841784) Multiple sclerosis ( 31604244 21833088) Systolic blood pressure ( 30224653)	Glycated hemoglobin levels ( 28898252) LDL cholesterol ( 30275531) Red blood cell count ( 27863252) Red cell distribution width ( 27863252) Total cholesterol levels ( 29083408) Triglycerides ( 30275531 27036123)
Interacting Genes		9 interacting genes: BMPR2 ERBB2 GAS6 GRB2 IKBKG LMO4 NEDD4L TNK2 VAV1	3 interacting genes: AXL MERTK TYRO3
Entrez ID		10461	2621
HPRD ID		05269	02705
Ensembl ID		ENSG00000153208	ENSG00000183087
Uniprot IDs		Q12866	Q14393
PDB IDs		2DBJ 2P0C 3BPR 3BRB 3TCP 4M3Q 4MH7 4MHA 5K0K 5K0X 5TC0 5TD2 5U6C 6MEP	1H30 2C5D 4RA0 5VXZ
Enriched GO Terms of Interacting Partners?
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