TAB1 and POLR3D

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		TAB1	POLR3D
Description		TGF-beta activated kinase 1 (MAP3K7) binding protein 1	RNA polymerase III subunit D
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Endosome Membrane Nuclear Speck Protein-containing Complex	Nuclear Chromatin Nucleoplasm RNA Polymerase III Complex Cytosol Nuclear Speck
	Molecular Function	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Enzyme Activator Activity Kinase Activator Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase P38 Binding	DNA Binding Chromatin Binding
	Biological Process	Activation Of MAPKKK Activity Activation Of MAPK Activity In Utero Embryonic Development Stimulatory C-type Lectin Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Heart Morphogenesis Cardiac Septum Development Protein Dephosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Protein Deubiquitination Lung Development Aorta Development Fc-epsilon Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Coronary Vasculature Development Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway	Transcription By RNA Polymerase III Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus
Pathways		NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs		Manganese
Diseases
GWAS		Factor VIII levels ( 30586737) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 23128233) Intelligence (MTAG) ( 29326435) Schizophrenia ( 29483656) Sleep duration (short sleep) ( 30846698) vWF levels ( 30586737) Waist circumference ( 28552196)	Hypertriglyceridemia ( 23505323)
Interacting Genes		72 interacting genes: AATK ACAP3 ARAP1 ASRGL1 BMPR1A C9orf78 CARD11 CASP6 CDK5RAP3 CFL1 CKB CORO1A DBN1 DVL2 EGFR EPRS1 ERBB4 FADD FN1 GIT1 HNRNPR IKBKG ITCH KIFC2 LAP3 LCMT1 LNX2 MAP3K1 MAP3K7 MAPK11 MAPK14 MAPKAPK5 MICAL1 MON1A MTG2 NR2C2 NXPH3 OGT PDCD6IP PHACTR3 PHC2 POLDIP2 POLR3D PPP1R7 PPP2CB PPP2R1A PRKAR1A PTPMT1 RBX1 ROR2 RPL10 RPLP1 SERPINA4 SMAD6 SMAD7 SMURF1 SNRNP35 TAB2 TAB3 TRAF2 TRAF6 TRIP6 TRPC4AP TSSC4 UBC URB1 WDCP WTAP XIAP XPO7 YWHAG ZMYND11	13 interacting genes: APEX1 ATF3 HNRNPAB HOXA10 HOXC9 MAPK11 MSX2 NR2E3 POLR3E RBFOX2 RHOXF2 TAB1 ZNF496
Entrez ID		10454	661
HPRD ID		04012	01755
Ensembl ID		ENSG00000100324	ENSG00000168495
Uniprot IDs		A8K6K3 Q15750	P05423
PDB IDs		2J4O 2POM 2POP 2YDS 2YIY 4AY5 4AY6 4GS6 4KA3 4L3P 4L52 4L53 4O91 5DIY 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5NZZ 5O90 5V5N 5VVU
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?