PAK4 and FBXO25

Number of citations of the paper that reports this interaction (PubMedID 23940030)
5

Data Source:
BioGRID (enzymatic study)

		PAK4	FBXO25
Description		p21 (RAC1) activated kinase 4	F-box protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Adherens Junction Focal Adhesion	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Involved In Cell-cell Adhesion	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	Regulation Of Cell Growth Apoptotic Process Cytoskeleton Organization Cell Cycle Signal Transduction Regulation Of Mitotic Cell Cycle Cell Migration Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Angiogenesis Dendritic Spine Development Cellular Response To Organic Cyclic Compound Cell-cell Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process	Protein Ubiquitination
Pathways		Activation of RAC1
Drugs
Diseases
GWAS			Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		24 interacting genes: APP CDC42 DGCR6L DLST FBXO25 FGFR2 G6PD GATAD2A GRB2 H1-1 ITGAV ITGB5 LIMK1 POT1 PPARG RAN RHOU SH3RF2 SRPK1 SRPK2 TERF1 YWHAG YWHAQ YWHAZ	82 interacting genes: ANKRD13A APLF AXL BMX C19orf57 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		10298	26260
HPRD ID		05675	16439
Ensembl ID		ENSG00000130669	ENSG00000147364
Uniprot IDs		A0A024R0J1 A0A024R0L8 O96013	A0A024QZ88 Q8TCJ0
PDB IDs		2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU 5BMS 5I0B 5UPK 5UPL 5VED 5VEE 5VEF 5XVA 5XVF 5XVG 5ZJW
Enriched GO Terms of Interacting Partners?
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