LILRB2 and FCGR1A

Number of citations of the paper that reports this interaction (PubMedID 9842885)
34

Data Source:
HPRD (in vitro)

		LILRB2	FCGR1A
Description		leukocyte immunoglobulin like receptor B2	Fc fragment of IgG receptor Ia
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Plasma Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Phosphatase 1 Binding MHC Class Ib Protein Complex Binding MHC Class Ib Protein Binding Inhibitory MHC Class I Receptor Activity MHC Class I Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Cell Adhesion Molecule Binding	Protein Binding IgG Binding
	Biological Process	Adaptive Immune Response Negative Regulation Of Antigen Processing And Presentation Positive Regulation Of Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Learning Or Memory Positive Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Positive Regulation Of Protein Dephosphorylation Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Neutrophil Degranulation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Immune Response Negative Regulation Of Protein Metabolic Process Negative Regulation Of Calcium Ion Transport Cellular Response To Lipopolysaccharide Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Depression Negative Regulation Of Postsynaptic Density Organization Regulation Of Dendritic Cell Differentiation	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Receptor-mediated Endocytosis Phagocytosis, Engulfment Immune Response Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways			Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Interferon gamma signaling FCGR3A-mediated IL10 synthesis
Drugs			Cetuximab Etanercept Immune Globulin Human Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Porfimer sodium Methyl aminolevulinate Sarilumab
Diseases
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576 29875488) HDL cholesterol ( 20686565) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lactate dehydrogenase levels ( 29403010) Nonsyndromic cleft lip ( 31609978)
Interacting Genes		7 interacting genes: FCGR1A HLA-A HLA-B HLA-C HLA-F HLA-G PTPN6	10 interacting genes: APCS CRKL CRP FCAR FCGR3A HCK HRG LAT LILRB2 SYK
Entrez ID		10288	2209
HPRD ID		11994	00904
Ensembl ID		ENSG00000131042	ENSG00000150337
Uniprot IDs		A2IXV5	P12314
PDB IDs			3RJD 4W4O 4X4M 4ZNE
Enriched GO Terms of Interacting Partners?
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