SAP18 and SUFU

Number of citations of the paper that reports this interaction (PubMedID 11960000)
75

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		SAP18	SUFU
Description		Sin3A associated protein 18	SUFU negative regulator of hedgehog signaling
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GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleoplasm Cytosol Nuclear Body Nuclear Speck Exon-exon Junction Complex ASAP Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Ciliary Tip Ciliary Base
	Molecular Function	Transcription Corepressor Activity RNA Binding Protein Binding	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Apoptotic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Neural Tube Closure Heart Looping Ventricular Septum Development Regulation Of Transcription, DNA-templated Proteolysis Signal Transduction Multicellular Organism Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Aorta Development Negative Regulation Of Protein Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Skin Development Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Coronary Vasculature Development Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		HDACs deacetylate histones NoRC negatively regulates rRNA expression	Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state
Drugs
Diseases			Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome
GWAS			Allergy ( 27182965) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Height ( 28552196) Nickel levels ( 26025379) Optic disc size ( 31809533) Prostate cancer ( 23535732) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White blood cell count ( 29403010)
Interacting Genes		12 interacting genes: HDAC1 IKZF1 INCA1 NOL12 POLE2 RBM39 RNPS1 RPS3A SIN3A SUFU TADA3 TSC22D2	27 interacting genes: BTRC FBXL17 GLI1 GLI2 GLI3 GLIS3 HDX HMGA1 HNRNPA1 ITCH LAMTOR3 LGALS3 MID1IP1 NCOA3 PEX26 PIAS1 QPRT RBPJ RCN3 RNF19A SAP18 SETDB1 STK36 ZNF219 ZNF263 ZNF446 ZNF764
Entrez ID		10284	51684
HPRD ID		04256	06124
Ensembl ID		ENSG00000150459	ENSG00000107882
Uniprot IDs		O00422	A0A223LX15 Q9UMX1
PDB IDs		2HDE	1M1L 4BL8 4BL9 4BLA 4BLB 4BLD 4KM8 4KM9 4KMD 4KMH
Enriched GO Terms of Interacting Partners?
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