UBE4B and CASP7

Number of citations of the paper that reports this interaction (PubMedID 11802788)
8

Data Source:
HPRD (in vitro)

		UBE4B	CASP7
Description		ubiquitination factor E4B	caspase 7
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	ATP Binding Enzyme Binding Ubiquitin-ubiquitin Ligase Activity ATPase Binding	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Protein Polyubiquitination Ventricular Trabecula Myocardium Morphogenesis Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Granzyme-mediated Apoptotic Signaling Pathway Response To UV Ubiquitin-dependent ERAD Pathway Neuron Projection Development Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination	Proteolysis Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis
Pathways			Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins
Drugs			Fica Emricasan
Diseases
GWAS		Atrial fibrillation ( 29892015) Hepatocellular carcinoma ( 20676096) Resting heart rate ( 27798624)	Smoking status (ever vs never smokers) ( 30643258) Vitiligo ( 27723757 22561518)
Interacting Genes		22 interacting genes: ATXN3 CASP3 CASP6 CASP7 CDKN2A DNAJC7 ESR1 FEZ1 GZMB HGS HRAS MAPK3 OTUB1 PGAM5 PPP3CA PRMT1 RAD23A TRIP12 UBE2D2 UBE2D3 VAV2 VCP	61 interacting genes: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HSPA5 KRT18 LYN MAPT MAX MEF2A MEF2D NEDD4 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SLC30A9 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A UBE4B VIM XIAP
Entrez ID		10277	840
HPRD ID		11659	03457
Ensembl ID		ENSG00000130939	ENSG00000165806
Uniprot IDs		O95155	A0A0A0MRL7 B4DWA2 P55210
PDB IDs		2KRE 3L1X 3L1Z 5O75	1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1MIA 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2 4LSZ 4ZVO 4ZVP 4ZVQ 4ZVR 4ZVS 4ZVT 4ZVU 5IC6 5K20 5V6U 5V6Z
Enriched GO Terms of Interacting Partners?
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