CALCOCO2 and HDAC7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		CALCOCO2	HDAC7
Description		calcium binding and coiled-coil domain 2	histone deacetylase 7
Image
GO Annotations	Cellular Component	Autophagosome Membrane Nucleus Cytoplasm Autophagosome Cytosol Cytoskeleton Membrane PML Body Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Homodimerization Activity Metal Ion Binding	Chromatin Binding Transcription Corepressor Activity Protein Kinase C Binding Protein Binding Protein Kinase Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Activating Transcription Factor Binding Metal Ion Binding Repressing Transcription Factor Binding 14-3-3 Protein Binding
	Biological Process	Viral Process Response To Interferon-gamma Xenophagy Positive Regulation Of Autophagosome Maturation	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Cell-cell Junction Assembly Negative Regulation Of Interleukin-2 Production Negative Regulation Of Osteoblast Differentiation Histone H3 Deacetylation Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of NIK/NF-kappaB Signaling
Pathways			NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants SUMOylation of DNA damage response and repair proteins Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs			7-[4-(Dimethylamino)Phenyl]-N-Hydroxy-4,6-Dimethyl-7-Oxo-2,4-Heptadienamide Belinostat Panobinostat
Diseases
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Type 2 diabetes ( 29358691 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 30929738) Asthma (adult onset) ( 31036433 30929738) Bipolar disorder ( 31043756) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Diastolic blood pressure ( 27841878) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Primary sclerosing cholangitis ( 23603763) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908) Urate levels ( 23263486)
Interacting Genes		150 interacting genes: ABLIM1 ADSL AKAP17A AMMECR1 AP5B1 APEX2 ARHGEF39 ARHGEF5 ARNT2 ATG5 AXIN1 BAHD1 BCL6B BEX2 CBX8 CCDC185 CCDC33 CCNH CEP57L1 CHCHD3 CPNE7 CWF19L2 DAXX DAZAP2 DBNDD2 DCTN4 DCX DDIT4L DDX6 DOCK2 DUSP12 DUSP26 EEF1E1 ELOA2 ENKD1 EXOSC5 FAM107A FAM161A FAM168A FAM189A2 FAM90A1 FARS2 FASTK FBF1 FBXL18 FKBPL FNDC11 FXR2 GABARAPL1 GABARAPL2 GATAD2B GEMIN4 GIT2 GLYCTK HDAC7 HLX HNRNPLL HOXB9 IKBKG KANSL1 KAT7 KLHL42 LENG1 LGALS8 LIMS2 LITAF LMF2 LMO2 LMO4 LNX1 LONRF1 LSM4 MAGOHB MAVS MCM10 METTL17 MID2 MOS MTPAP MVP MXI1 MYH6 MYO6 NAA10 NDN NFU1 ORC5 PCGF1 PEF1 PEG10 PFDN5 PHF1 PIAS4 POLI POLR2A PPP1R18 PRKAB2 PRPF31 PSMA1 PSME4 PTBP1 PTBP2 RAB35 RABL6 RB1CC1 RBM15 RHPN1 RIN1 RNF11 RPA2 RPL9 RPS27A RTN4IP1 RTP5 RXRB SDCBP SHC1 SLC15A3 SMARCD1 SMCP SNRPB SPATA24 SRI STK16 TBC1D22B TBK1 TBRG4 TCL1A TEKT3 TENT2 TLE5 TP53RK TRAF2 TRAF4 TRAF6 TTC23L UBAC2 VARS1 VPS72 ZC2HC1C ZNF101 ZNF205 ZNF337 ZNF408 ZNF426 ZNF451 ZNF564 ZNF581 ZNF638 ZNF688	29 interacting genes: ACTN4 BCL6 CALCOCO2 CASP8 EDNRA EGFR GNMT HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 KAT5 MARK2 MARK3 MEF2A MEF2C NCOR2 PPARD PRKD1 PRKD2 REL RIPPLY1 RUNX2 SIN3A UBE2I YWHAG YWHAQ ZBTB16
Entrez ID		10241	51564
HPRD ID		06846	09133
Ensembl ID		ENSG00000136436	ENSG00000061273
Uniprot IDs		Q13137	Q8WUI4
PDB IDs		2MXP 3VVV 3VVW 4GXL 4HAN 4XKL 5AAQ 5Z7A 5Z7L	3C0Y 3C0Z 3C10 3ZNR 3ZNS
Enriched GO Terms of Interacting Partners?
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