TRIB1 and CEBPE

Number of citations of the paper that reports this interaction (PubMedID 30254053)
5

Data Source:
BioGRID (unspecified method)

		TRIB1	CEBPE
Description		tribbles pseudokinase 1	CCAAT enhancer binding protein epsilon
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nuclear Chromatin Nucleus
	Molecular Function	Protein Kinase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Protein Phosphorylation Negative Regulation Of Protein Kinase Activity JNK Cascade Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Lipopolysaccharide Regulation Of MAP Kinase Activity Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Eosinophil Differentiation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation	Phagocytosis Defense Response Macrophage Differentiation Granulocyte Differentiation Cytokine Biosynthetic Process Defense Response To Bacterium Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide
Pathways		NGF-stimulated transcription	Transcriptional regulation of granulopoiesis
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Adiponectin levels ( 22479202) Alanine transaminase levels ( 29403010) Birth weight ( 31043758 27680694) C-reactive protein levels ( 30388399) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 19060911 25961943 20686565 26582766) Coronary artery disease ( 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Gamma glutamyl transferase levels ( 29403010) Glycine levels ( 31070104 30837465) HDL cholesterol ( 24097068 25961943 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hypertriglyceridemia ( 27599772) Inflammatory bowel disease ( 23128233) LDL cholesterol ( 24097068 20864672 19060911 25961943 20686565) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipid metabolism phenotypes ( 19936222) Lipid traits ( 24386095) Liver enzyme levels (alanine transaminase) ( 22001757) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 29403010) Metabolic syndrome ( 31589552) Metabolite levels ( 23823483) Metabolite levels (lipoprotein measures) ( 27005778) Microalbuminuria ( 31511532) Mosquito bite size ( 28199695) Myocardial infarction ( 26343387) Nonalcoholic fatty liver disease ( 31311600) Obesity-related traits ( 23251661) Response to statin therapy ( 20339536) Rosacea symptom severity ( 29771307) Serum alkaline phosphatase levels ( 29403010) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum total protein level ( 29403010) Systolic blood pressure ( 27841878) Total cholesterol levels ( 28334899 29403010) Triglyceride levels ( 28334899 31647587 30911093 29403010 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 18193043 18193044 20864672 19060906 24886709 20139978 25961943 26780889 20686565 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378 31511532) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) White blood cell count (basophil) ( 29403010)	Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612 22076464 23512250 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 29403010 27863252 28158719)
Interacting Genes		8 interacting genes: ALOX12 CEBPB CEBPD CEBPE COP1 MAP2K1 MAP2K4 MAP2K7	45 interacting genes: ALX4 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CCT7 CEBPA CEBPD CEBPG COPS3 CSNK1A1L DDIT3 DENND4A E2F1 EDA2R ELOB FOS FOSL1 GATA1 GPR22 GTF2A1L IL7 JUN KDM2B LDOC1 MED16 MLLT6 MYB NELFB PIAS1 POU2F1 PSAT1 RB1 SIPA1L1 SPI1 STAT6 TAF5L TBX2 TRIB1 UBE2I ZFP2 ZMYM2 ZNF384
Entrez ID		10221	1053
HPRD ID		09863	02852
Ensembl ID		ENSG00000173334	ENSG00000092067
Uniprot IDs		Q96RU8	Q15744
PDB IDs		5CEK 5CEM 5IGO 5IGQ 6DC0	3T92
Enriched GO Terms of Interacting Partners?
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