MPHOSPH6 and EXOSC1

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology, pull down)

		MPHOSPH6	EXOSC1
Description		M-phase phosphoprotein 6	exosome component 1
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytosol	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	RNA Binding Protein Binding	RNA Binding Exoribonuclease Activity Protein Binding
	Biological Process	Maturation Of 5.8S RRNA RRNA Processing	RRNA Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Leukocyte telomere length ( 31171785) Lung adenocarcinoma ( 28604730) Obesity-related traits ( 23251661) Seasonality and depression ( 30217971)	Blood protein levels ( 30072576) Early spontaneous preterm birth ( 31194736) Spontaneous preterm birth with premature rupture of membranes ( 31194736)
Interacting Genes		33 interacting genes: AATF APLP1 ARHGAP18 DNM2 DYNLRB1 EIF3G ERG28 EXOSC1 EXOSC10 EXOSC3 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL GDF9 HSBP1 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1	27 interacting genes: A2M APP CDC37 DMRTB1 ECSIT EXOC6 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FHL3 KCTD1 LSM3 MAST1 MPHOSPH6 NOS3 NUP160 PAK5 RBPMS REL RNF32 SH3GLB2 TCF4 TEX11 UPF2 XRN1
Entrez ID		10200	51013
HPRD ID		16111	16223
Ensembl ID		ENSG00000135698	ENSG00000171311
Uniprot IDs		H3BNT4 Q99547	B1AMU3 Q9Y3B2
PDB IDs		6D6Q 6D6R 6H25	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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