TSPAN2 and MOV10

		TSPAN2	MOV10
Description		tetraspanin 2	Mov10 RISC complex RNA helicase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Integral Component Of Plasma Membrane Integral Component Of Membrane Myelin Sheath	P-body Extracellular Space Nucleus Cytosol Cytoplasmic Stress Granule Viral Replication Complex Cytoplasmic Ribonucleoprotein Granule P Granule
	Molecular Function	Protein Binding	RNA Binding Protein Binding ATP Binding 5'-3' RNA Helicase Activity
	Biological Process	Inflammatory Response Brain Development Astrocyte Development Microglia Development Myelination Oligodendrocyte Differentiation Axon Development	Wnt Signaling Pathway, Calcium Modulating Pathway Negative Regulation Of Transposition, RNA-mediated Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Viral Process Posttranscriptional Gene Silencing By RNA Gene Silencing By MiRNA MRNA Cleavage Involved In Gene Silencing By MiRNA Regulation Of Megakaryocyte Differentiation Defense Response To Virus Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Regulation Of Neuron Projection Arborization
Pathways			Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Dysmenorrheic pain ( 27454463) Ischemic stroke (large artery atherosclerosis) ( 26708676 29531354) Migraine ( 27182965 23793025 27322543) Migraine without aura ( 23793025 27322543)	Blood pressure ( 21909110) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diastolic blood pressure ( 27841878 21909115 28739976 27618452 25249183 30487518) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Height ( 31562340) Hip circumference adjusted for BMI ( 25673412) Hypertension ( 21909115 25249183 30487518) Mean arterial pressure ( 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (diuretics) ( 31015401) Systolic blood pressure ( 27841878 21909115 28739976 27618452 25249183 30487518) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		7 interacting genes: CREB3 FOS GRB2 LMNA MOV10 PIK3R3 RABGAP1L	4 interacting genes: ADORA3 ATP5PB EIF2AK2 TSPAN2
Entrez ID		10100	4343
HPRD ID		18233	14732
Ensembl ID		ENSG00000134198	ENSG00000155363
Uniprot IDs		B1AKP1 B2RD31 O60636	Q5JR04 Q9HCE1
PDB IDs
Enriched GO Terms of Interacting Partners?
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