ACTR2 and ARPC4

Number of citations of the paper that reports this interaction (PubMedID 11721045)
173

Data Source:
BioGRID (proximity labelling technology)
HPRD (in vivo, in vitro)

		ACTR2	ARPC4
Description		actin related protein 2	actin related protein 2/3 complex subunit 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cell Nucleus Cytoplasm Cytosol Arp2/3 Protein Complex Focal Adhesion Postsynaptic Density Actin Cytoskeleton Membrane Lamellipodium Actin Cap Actin Cortical Patch Azurophil Granule Lumen Site Of Double-strand Break Podosome Core Extracellular Exosome Invadopodium Ficolin-1-rich Granule Lumen	Nucleus Cytosol Arp2/3 Protein Complex Site Of Double-strand Break Cell Projection Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton ATP Binding Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein Binding, Bridging Actin Filament Binding
	Biological Process	Establishment Or Maintenance Of Cell Polarity Associative Learning Asymmetric Cell Division Meiotic Chromosome Movement Towards Spindle Pole Cytosolic Transport Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Response To Immobilization Stress Cellular Response To Trichostatin A Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neutrophil Degranulation Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Spindle Localization Cilium Assembly Positive Regulation Of Dendritic Spine Morphogenesis Membrane Organization Cellular Response To Interferon-gamma Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Actin Nucleation Ephrin Receptor Signaling Pathway Membrane Organization
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Coronary artery disease ( 29212778) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 ELF5 HCLS1 IQGAP2 SHARPIN WASF1 WASF2 WASL	11 interacting genes: ACTR2 ACTR3 ARPC1B ARPC2 ARPC3 ARPC5 ARPC5L CLK1 NELFCD PNMA5 RNF130
Entrez ID		10097	10093
HPRD ID		05023	10368
Ensembl ID		ENSG00000138071	ENSG00000241553
Uniprot IDs		P61160	P59998
PDB IDs
Enriched GO Terms of Interacting Partners?
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