ARPC1B and ARPC2

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, proximity labelling technology, affinity chromatography technology, biochemical, biochemical)
HPRD (in vitro, in vivo)

		ARPC1B	ARPC2
Description		actin related protein 2/3 complex subunit 1B	actin related protein 2/3 complex subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Tubulobulbar Complex Extracellular Exosome	Nucleus Endosome Cytosol Arp2/3 Protein Complex Focal Adhesion Actin Cytoskeleton Lamellipodium Site Of Double-strand Break Muscle Cell Projection Membrane Neuron Projection Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding	Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Response To Estradiol Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Estrogen Ephrin Receptor Signaling Pathway	Positive Regulation Of Lamellipodium Assembly Actin Filament Polymerization Arp2/3 Complex-mediated Actin Nucleation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ephrin Receptor Signaling Pathway Membrane Organization Actin Polymerization-dependent Cell Motility Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Alcohol consumption ( 31358974) Facial emotion recognition (sad faces) ( 28608620) Serum metabolite levels ( 23093944)	Inflammatory bowel disease ( 28067908 23128233) Mean platelet volume ( 27863252) Neutrophil count ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 27863252) Platelet distribution width ( 27863252) White blood cell count ( 25096241 29403010)
Interacting Genes		11 interacting genes: ACTB ACTR2 APP ARPC2 ARPC4 ARPC5 AURKA PAK1 PMPCB SRPK2 WAS	8 interacting genes: ACTR3 ARPC1B ARPC4 AURKA CORO1B MDN1 WAS ZYG11B
Entrez ID		10095	10109
HPRD ID		10366	10367
Ensembl ID		ENSG00000130429	ENSG00000163466
Uniprot IDs		A4D275 O15143	A0A024R408 O15144 Q53R19
PDB IDs
Enriched GO Terms of Interacting Partners?
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