RANBP9 and HMBS

Number of citations of the paper that reports this interaction (PubMedID 12917623)
5

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		RANBP9	HMBS
Description		RAN binding protein 9	hydroxymethylbilane synthase
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane	Cytoplasm Cytosol
	Molecular Function	Protein Binding Ran GTPase Binding Enzyme Binding	Hydroxymethylbilane Synthase Activity
	Biological Process	MAPK Cascade Microtubule Nucleation Axon Guidance Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Peptidyl-pyrromethane Cofactor Linkage
Pathways		L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling	Heme biosynthesis
Drugs
Diseases			Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS		Breast cancer ( 29059683 23535729)
Interacting Genes		56 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 CACNA1G CALB1 CBS CCND1 CDK11B CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LMNA MAPK6 MET MKLN1 MPHOSPH8 NCOA6 NCOR2 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 YPEL5	3 interacting genes: APP RANBP9 ZDHHC17
Entrez ID		10048	3145
HPRD ID		04835	01440
Ensembl ID		ENSG00000010017	ENSG00000256269
Uniprot IDs		A0A024QZW3 Q96S59	P08397
PDB IDs		5JI7 5JI9 5JIU	3ECR 3EQ1 5M6R 5M7F
Enriched GO Terms of Interacting Partners?
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