FRAT1 and RABEP2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		FRAT1	RABEP2
Description		FRAT regulator of WNT signaling pathway 1	rabaptin, RAB GTPase binding effector protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intracellular Membrane-bounded Organelle	Early Endosome Centrosome Cytosol Ciliary Basal Body Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	GTPase Activator Activity Protein Binding Growth Factor Activity
	Biological Process	Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Disassembly	Endocytosis Signal Transduction Protein Transport Cell Projection Organization Positive Regulation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS			Adventurousness ( 30643258) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 31453325) Body mass index variance ( 31453325) Cannabis use ( 30150663) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Obesity ( 23563607)
Interacting Genes		13 interacting genes: DVL1 GPRASP2 GRN GSK3B KCNK5 KRT18 LAMC3 LMAN2 LTBP4 PLSCR1 PSMA3 RABEP2 TDRD7	7 interacting genes: FBXO25 FRAT1 MAP3K1 RAB4A RAB5A UBC VPS52
Entrez ID		10023	79874
HPRD ID		03935	17948
Ensembl ID		ENSG00000165879	ENSG00000177548
Uniprot IDs		Q92837	Q9H5N1
PDB IDs		1GNG 3ZRK 3ZRL 3ZRM 4AFJ 5OY4
Enriched GO Terms of Interacting Partners?
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