PDCD6 and CPNE4

Number of citations of the paper that reports this interaction (PubMedID 12522145)
33

Data Source:
HPRD (in vitro, two hybrid)

		PDCD6	CPNE4
Description		programmed cell death 6	copine 4
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane COPII Vesicle Coat Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Extracellular Exosome Endoplasmic Reticulum Exit Site	Plasma Membrane Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Protein Binding, Bridging Identical Protein Binding Protein Homodimerization Activity Protein Membrane Anchor Protein Dimerization Activity Calcium-dependent Protein Binding Protein Binding, Bridging Involved In Substrate Recognition For Ubiquitination	Protein Binding Calcium-dependent Phospholipid Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endothelial Cell Migration Neural Crest Formation Neural Crest Cell Development Protein Ubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis COPII Vesicle Coating Response To Calcium Ion Negative Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway Positive Regulation Of Protein Monoubiquitination	Cellular Response To Calcium Ion
Pathways
Drugs		Calcium Zinc Calcium Citrate Calcium Phosphate
Diseases
GWAS			Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amyotrophic lateral sclerosis ( 22959728) Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Body mass index ( 31453325 28892062 25673413) Body mass index variance ( 31453325) Circulating leptin levels in high cardiovascular risk ( 31766143) Coronary artery aneurysm in Kawasaki disease ( 27171184) Intracranial aneurysm ( 29531279) Iron status biomarkers (total iron binding capacity) ( 28334935) Metabolic syndrome ( 31589552) Motion sickness ( 25628336) Neutrophil count ( 21507922)
Interacting Genes		20 interacting genes: ANXA11 ANXA7 CDKN2A CPNE1 CPNE2 CPNE4 CUL3 FAS FASLG HEBP2 IGFALS MAP3K5 MAPK1IP1L PDCD6IP PEF1 SEC31A SH3KBP1 TIMM22 VPS37C YWHAQ	16 interacting genes: ACTB BCOR BICD1 CCDC22 CEP162 CPNE1 MAP2K1 MYCBP PDCD6 PITPNM2 PPP5C RDX SKIL SPTBN1 UBE2M UBE2O
Entrez ID		10016	131034
HPRD ID		03035	05017
Ensembl ID		ENSG00000249915	ENSG00000196353
Uniprot IDs		A0A024QZ42 A0A087WZ38 O75340 Q53FC3	B7Z370 Q4G168 Q96A23
PDB IDs		2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK 3WXA 5GQQ
Enriched GO Terms of Interacting Partners?
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