ACOT8 and PEX5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, affinity chromatography technology, unspecified method, affinity chromatography technology)

		ACOT8	PEX5
Description		acyl-CoA thioesterase 8	peroxisomal biogenesis factor 5
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisomal Matrix Cytosol	Cytoplasm Peroxisome Peroxisomal Membrane Golgi Apparatus Cytosol Membrane Protein-containing Complex
	Molecular Function	Acetyl-CoA Hydrolase Activity Succinyl-CoA Hydrolase Activity Protein Binding CoA Hydrolase Activity Palmitoyl-CoA Hydrolase Activity Choloyl-CoA Hydrolase Activity Acetoacetyl-CoA Hydrolase Activity Acyl-CoA Hydrolase Activity Hydroxymethylglutaryl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Medium-chain Acyl-CoA Hydrolase Activity Long-chain Acyl-CoA Hydrolase Activity Myristoyl-CoA Hydrolase Activity	Peroxisome Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Protein Binding Enzyme Binding Small GTPase Binding Peroxisome Membrane Targeting Sequence Binding Protein N-terminus Binding
	Biological Process	Protein Targeting To Peroxisome Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Fatty Acid Catabolic Process Viral Process Peroxisome Fission Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Dicarboxylic Acid Catabolic Process Negative Regulation Of CD4 Biosynthetic Process	Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Docking Protein Ubiquitination Negative Regulation Of Protein Complex Assembly Protein Import Into Peroxisome Membrane
Pathways		Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol alpha-linolenic acid (ALA) metabolism Beta-oxidation of pristanoyl-CoA Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import	Pexophagy
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS			IgG glycosylation ( 23382691) Night sleep phenotypes ( 27126917)
Interacting Genes		3 interacting genes: FBXO7 PEX5 REL	71 interacting genes: ACD ACOT2 ACOT4 ACOT8 ACOX2 ACOX3 AGXT AMACR ANKRD50 ATM BAAT BRCA1 CAPRIN2 CCDC14 CROT DAO DDO DECR2 DHRS4 ECI2 EP400P1 EPHX2 FIS1 GDPD5 GNPAT GSTK1 HACL1 HAO1 HAO2 HMGCL HOXA7 HSPA1A IDE IDH1 LDHB LONP2 MKRN3 MLYCD MPV17 NOS2 NUDT19 NUDT3 NUDT7 PAOX PDZK1 PEX1 PEX10 PEX12 PEX13 PEX14 PEX26 PEX6 PEX7 PIPOX POT1 PRDX5 PRR13 RPL14 S100A6 SCARB1 SCP2 SIRT3 SLC27A2 SNUPN SSTR5 TINF2 TM6SF1 TOMM7 USP2 USP9X ZNF772
Entrez ID		10005	5830
HPRD ID		06998	02684
Ensembl ID		ENSG00000101473	ENSG00000139197
Uniprot IDs		A0A494C0N6 O14734	A0A0S2Z480 A0A0S2Z4F3 A0A0S2Z4H1 B4DR50 B4E0T2 P50542
PDB IDs			1FCH 2C0L 2C0M 2J9Q 2W84 3R9A 4BXU 4KXK 4KYO
Enriched GO Terms of Interacting Partners?
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