AKT1 and HSP90AA1 |
v-akt murine thymoma viral oncogene homolog 1 |
heat shock protein 90kDa alpha (cytosolic), class A member 1 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Activation of BH3-only proteins
- Signaling by Wnt
- Platelet Aggregation (Plug Formation)
- Signaling by EGFRvIII in Cancer
- AKT phosphorylates targets in the cytosol
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Regulation of beta-cell development
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- DAP12 interactions
- Regulation of mRNA stability by proteins that bind AU-rich elements
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Activation of BAD and translocation to mitochondria
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by VEGF
- AKT phosphorylates targets in the nucleus
- Downstream signal transduction
- Regulation of gene expression in beta cells
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Costimulation by the CD28 family
- PIP3 activates AKT signaling
- Translocation of GLUT4 to the plasma membrane
- deactivation of the beta-catenin transactivating complex
- VEGFA-VEGFR2 Pathway
- Metabolism of nitric oxide
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- VEGFR2 mediated vascular permeability
- Downstream signaling of activated FGFR
- Programmed Cell Death
- XAV939 inhibits tankyrase, stabilizing AXIN
- eNOS activation and regulation
- Intrinsic Pathway for Apoptosis
- Butyrate Response Factor 1 (BRF1) destabilizes mRNA
- Innate Immune System
- Signalling by NGF
- CTLA4 inhibitory signaling
- AKT-mediated inactivation of FOXO1A
- Integrin alphaIIb beta3 signaling
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- NGF signalling via TRKA from the plasma membrane
- Negative regulation of the PI3K/AKT network
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Signaling by FGFR
- eNOS activation
- TCF dependent signaling in response to WNT
- KSRP destabilizes mRNA
- GPVI-mediated activation cascade
- Signaling by WNT in cancer
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- HSF1 activation
- Regulatory RNA pathways
- Signaling by EGFRvIII in Cancer
- Regulation of PLK1 Activity at G2/M Transition
- Influenza Life Cycle
- Influenza Viral RNA Transcription and Replication
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Uptake and actions of bacterial toxins
- EPH-Ephrin signaling
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Fcgamma receptor (FCGR) dependent phagocytosis
- Recruitment of mitotic centrosome proteins and complexes
- Regulation of actin dynamics for phagocytic cup formation
- vRNP Assembly
- Influenza Infection
- Signaling by ERBB2
- Signaling by VEGF
- Signaling by EGFR in Cancer
- Sema3A PAK dependent Axon repulsion
- Mitotic G2-G2/M phases
- Uptake and function of diphtheria toxin
- PIWI-interacting RNA (piRNA) biogenesis
- Organelle biogenesis and maintenance
- Axon guidance
- Attenuation phase
- G2/M Transition
- VEGFA-VEGFR2 Pathway
- HSF1-dependent transactivation
- EPHA-mediated growth cone collapse
- Metabolism of nitric oxide
- VEGFR2 mediated vascular permeability
- Loss of Nlp from mitotic centrosomes
- Scavenging by Class F Receptors
- eNOS activation and regulation
- Innate Immune System
- Semaphorin interactions
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Assembly of the primary cilium
- Cellular response to heat stress
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- eNOS activation
- Loss of proteins required for interphase microtubule organization from the centrosome
- Centrosome maturation
- Constitutive Signaling by EGFRvIII
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- Adenosine triphosphate
- Arsenic trioxide
- Inositol 1,3,4,5-Tetrakisphosphate
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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- Rifabutin
- Nedocromil
- 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine
- Geldanamycin
- 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
- 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine
- 4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid
- 17-Dmag
- 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine
- 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-Ylamine
- Adenosine-5\'-Diphosphate
- 9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine
- 4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole
- 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine
- 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine
- 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine
- 8-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-Ylamine
- 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
- N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE
- N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE
- 4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL
- 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE
- 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide
- 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE
- 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
- 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL
- (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one
- 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE
- 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE
- N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE
- 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE
- 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol
- 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL
- 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol
- 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE
- 4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine
- (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime
- 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H-
- 4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol
- 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol
- 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide
- 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine
- 4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine
- 3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE
- 2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE
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AKT2 and HSP90AA1 |
v-akt murine thymoma viral oncogene homolog 2 |
heat shock protein 90kDa alpha (cytosolic), class A member 1 |
- Signaling by the B Cell Receptor (BCR)
- Signaling by GPCR
- Signaling by FGFR in disease
- Activation of BH3-only proteins
- mTOR signalling
- Signaling by Wnt
- Activation of PKB
- Signaling by EGFRvIII in Cancer
- AKT phosphorylates targets in the cytosol
- Signaling by SCF-KIT
- Downstream signaling events of B Cell Receptor (BCR)
- DAP12 signaling
- Regulation of beta-cell development
- PI3K/AKT activation
- PI-3K cascade
- RNF mutants show enhanced WNT signaling and proliferation
- PDE3B signalling
- PKB-mediated events
- PI3K Cascade
- Signaling by PDGF
- Downregulation of ERBB2:ERBB3 signaling
- DAP12 interactions
- GAB1 signalosome
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- G-protein beta:gamma signalling
- CD28 co-stimulation
- CD28 dependent PI3K/Akt signaling
- PDE3B signalling
- Signaling by ERBB4
- Role of LAT2/NTAL/LAB on calcium mobilization
- Constitutive PI3K/AKT Signaling in Cancer
- PI3K events in ERBB4 signaling
- Signaling by ERBB2
- Activation of BAD and translocation to mitochondria
- Signaling by EGFR
- GPCR downstream signaling
- Signaling by VEGF
- AKT phosphorylates targets in the nucleus
- Downstream signal transduction
- Regulation of gene expression in beta cells
- Signaling by EGFR in Cancer
- Fc epsilon receptor (FCERI) signaling
- PI3K/AKT Signaling in Cancer
- Platelet activation, signaling and aggregation
- Adaptive Immune System
- Inhibition of TSC complex formation by PKB
- Activation of PKB
- Costimulation by the CD28 family
- IRS-mediated signalling
- PIP3 activates AKT signaling
- mTOR signalling
- Translocation of GLUT4 to the plasma membrane
- IGF1R signaling cascade
- deactivation of the beta-catenin transactivating complex
- VEGFA-VEGFR2 Pathway
- IRS-related events triggered by IGF1R
- G beta:gamma signalling through PI3Kgamma
- PI3K events in ERBB2 signaling
- VEGFR2 mediated vascular permeability
- Downstream signaling of activated FGFR
- Programmed Cell Death
- XAV939 inhibits tankyrase, stabilizing AXIN
- Intrinsic Pathway for Apoptosis
- Signaling by Insulin receptor
- Innate Immune System
- Signalling by NGF
- Insulin receptor signalling cascade
- CTLA4 inhibitory signaling
- AKT-mediated inactivation of FOXO1A
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- IRS-related events
- NGF signalling via TRKA from the plasma membrane
- Negative regulation of the PI3K/AKT network
- Signaling by Overexpressed Wild-Type EGFR in Cancer
- Inhibition of TSC complex formation by PKB
- Signaling by FGFR
- IRS-mediated signalling
- TCF dependent signaling in response to WNT
- Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
- GPVI-mediated activation cascade
- Signaling by WNT in cancer
- PKB-mediated events
- PI3K Cascade
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- HSF1 activation
- Regulatory RNA pathways
- Signaling by EGFRvIII in Cancer
- Regulation of PLK1 Activity at G2/M Transition
- Influenza Life Cycle
- Influenza Viral RNA Transcription and Replication
- Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
- Uptake and actions of bacterial toxins
- EPH-Ephrin signaling
- Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
- Fcgamma receptor (FCGR) dependent phagocytosis
- Recruitment of mitotic centrosome proteins and complexes
- Regulation of actin dynamics for phagocytic cup formation
- vRNP Assembly
- Influenza Infection
- Signaling by ERBB2
- Signaling by VEGF
- Signaling by EGFR in Cancer
- Sema3A PAK dependent Axon repulsion
- Mitotic G2-G2/M phases
- Uptake and function of diphtheria toxin
- PIWI-interacting RNA (piRNA) biogenesis
- Organelle biogenesis and maintenance
- Axon guidance
- Attenuation phase
- G2/M Transition
- VEGFA-VEGFR2 Pathway
- HSF1-dependent transactivation
- EPHA-mediated growth cone collapse
- Metabolism of nitric oxide
- VEGFR2 mediated vascular permeability
- Loss of Nlp from mitotic centrosomes
- Scavenging by Class F Receptors
- eNOS activation and regulation
- Innate Immune System
- Semaphorin interactions
- Signaling by Ligand-Responsive EGFR Variants in Cancer
- Assembly of the primary cilium
- Cellular response to heat stress
- Anchoring of the basal body to the plasma membrane
- Cell Cycle, Mitotic
- eNOS activation
- Loss of proteins required for interphase microtubule organization from the centrosome
- Centrosome maturation
- Constitutive Signaling by EGFRvIII
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- N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
- 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
- ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
- (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
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- Rifabutin
- Nedocromil
- 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine
- Geldanamycin
- 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
- 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine
- 4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid
- 17-Dmag
- 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine
- 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-Ylamine
- Adenosine-5\'-Diphosphate
- 9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine
- 4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole
- 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine
- 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine
- 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine
- 8-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-Ylamine
- 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine
- N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE
- N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE
- 4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL
- 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE
- 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide
- 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE
- 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide
- 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL
- (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one
- 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE
- 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE
- N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE
- 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE
- 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol
- 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL
- 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol
- 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE
- 4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine
- (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime
- 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H-
- 4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol
- 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol
- 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide
- 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine
- 4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine
- 3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE
- 2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE
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ABCD1 and RPSA |
ATP-binding cassette, sub-family D (ALD), member 1 |
ribosomal protein SA |
- alpha-linolenic acid (ALA) metabolism
- ABC-family proteins mediated transport
- Metabolism of lipids and lipoproteins
- alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
- Linoleic acid (LA) metabolism
- Beta-oxidation of very long chain fatty acids
- ABCA transporters in lipid homeostasis
- Peroxisomal lipid metabolism
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- Nonsense-Mediated Decay (NMD)
- Translation initiation complex formation
- Translation
- SRP-dependent cotranslational protein targeting to membrane
- Eukaryotic Translation Termination
- Peptide chain elongation
- Influenza Infection
- Viral mRNA Translation
- L13a-mediated translational silencing of Ceruloplasmin expression
- Influenza Life Cycle
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Ribosomal scanning and start codon recognition
- Formation of the ternary complex, and subsequently, the 43S complex
- Influenza Viral RNA Transcription and Replication
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Initiation
- Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
- Formation of a pool of free 40S subunits
- Eukaryotic Translation Elongation
- Cap-dependent Translation Initiation
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
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ALDH2 and RPL13A |
aldehyde dehydrogenase 2 family (mitochondrial) |
ribosomal protein L13a |
- Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B)
- Metabolic disorders of biological oxidation enzymes
- Ethanol oxidation
- Phase 1 - Functionalization of compounds
- Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A)
- Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4)
- Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56)
- Biological oxidations
- Serotonin clearance from the synaptic cleft
- Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD)
- Defective FMO3 causes Trimethylaminuria (TMAU)
- Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)
- Metabolism of serotonin
- Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX)
- Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4)
- Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA)
- Defective CYP1B1 causes Glaucoma
- Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
- Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3)
- Defective CYP19A1 causes Aromatase excess syndrome (AEXS)
- Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5)
- Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
- Neurotransmitter Clearance In The Synaptic Cleft
- Defective MAOA causes Brunner syndrome (BRUNS)
- Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency)
- Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
- Transmission across Chemical Synapses
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- Nonsense-Mediated Decay (NMD)
- Translation
- SRP-dependent cotranslational protein targeting to membrane
- Eukaryotic Translation Termination
- Peptide chain elongation
- Influenza Infection
- Viral mRNA Translation
- L13a-mediated translational silencing of Ceruloplasmin expression
- Influenza Life Cycle
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
- Influenza Viral RNA Transcription and Replication
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Initiation
- Formation of a pool of free 40S subunits
- Eukaryotic Translation Elongation
- Cap-dependent Translation Initiation
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
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- NADH
- Guanidine
- Disulfiram
- Nicotinamide-Adenine-Dinucleotide
- Daidzin
- Crotonaldehyde
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AMFR and KPNB1 |
autocrine motility factor receptor, E3 ubiquitin protein ligase |
karyopherin (importin) beta 1 |
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- Metabolism of lipids and lipoproteins
- ISG15 antiviral mechanism
- Nuclear import of Rev protein
- HIV Infection
- Interferon Signaling
- Apoptotic execution phase
- Host Interactions of HIV factors
- Cytokine Signaling in Immune system
- Interactions of Rev with host cellular proteins
- Influenza Infection
- Antiviral mechanism by IFN-stimulated genes
- Influenza Life Cycle
- Regulation of cholesterol biosynthesis by SREBP (SREBF)
- Activation of DNA fragmentation factor
- Transport of Ribonucleoproteins into the Host Nucleus
- Apoptosis induced DNA fragmentation
- Programmed Cell Death
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SLC25A6 and VIM |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
vimentin |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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- Apoptotic cleavage of cellular proteins
- Striated Muscle Contraction
- Programmed Cell Death
- Apoptotic execution phase
- Caspase-mediated cleavage of cytoskeletal proteins
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SLC25A6 and NOTCH2NL |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
notch 2 N-terminal like |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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SLC25A6 and KARS |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
lysyl-tRNA synthetase |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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- Cytosolic tRNA aminoacylation
- tRNA Aminoacylation
- Mitochondrial tRNA aminoacylation
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SLC25A6 and MID2 |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
midline 2 |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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SLC25A6 and TRIP6 |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
thyroid hormone receptor interactor 6 |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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SLC25A6 and MTUS2 |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
microtubule associated tumor suppressor candidate 2 |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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SLC25A6 and KRTAP4-12 |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
keratin associated protein 4-12 |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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SLC25A6 and STRN4 |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
striatin, calmodulin binding protein 4 |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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SLC25A6 and KRT31 |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
keratin 31, type I |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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SLC25A6 and TEKT4 |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
tektin 4 |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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SLC25A6 and CHGB |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
chromogranin B (secretogranin 1) |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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SLC25A6 and LZTS2 |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
leucine zipper, putative tumor suppressor 2 |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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SLC25A6 and TRAF1 |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
TNF receptor-associated factor 1 |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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SLC25A6 and PRSS23 |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
protease, serine, 23 |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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SLC25A6 and PLSCR1 |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
phospholipid scramblase 1 |
- Integration of energy metabolism
- Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization
- HIV Infection
- Regulation of insulin secretion
- Host Interactions of HIV factors
- Mitochondrial protein import
- Host Interactions with Influenza Factors
- Influenza Infection
- Influenza Virus Induced Apoptosis
- Interactions of Vpr with host cellular proteins
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