| CANX and SMURF2 |
calnexin |
SMAD specific E3 ubiquitin protein ligase 2 |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- Loss of Function of TGFBR2 in Cancer
- Antigen processing: Ubiquitination & Proteasome degradation
- Downregulation of TGF-beta receptor signaling
- SMAD2/3 MH2 Domain Mutants in Cancer
- TGF-beta receptor signaling activates SMADs
- Signaling by Wnt
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- TGFBR1 LBD Mutants in Cancer
- Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
- Signaling by BMP
- Generic Transcription Pathway
- RNF mutants show enhanced WNT signaling and proliferation
- Hedgehog 'on' state
- XAV939 inhibits tankyrase, stabilizing AXIN
- Class I MHC mediated antigen processing & presentation
- TGFBR2 MSI Frameshift Mutants in Cancer
- SMAD2/3 Phosphorylation Motif Mutants in Cancer
- misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
- Loss of Function of SMAD2/3 in Cancer
- TGFBR2 Kinase Domain Mutants in Cancer
- Loss of Function of SMAD4 in Cancer
- TGFBR1 KD Mutants in Cancer
- Loss of Function of TGFBR1 in Cancer
- beta-catenin independent WNT signaling
- Signaling by TGF-beta Receptor Complex
- Signaling by TGF-beta Receptor Complex in Cancer
- TCF dependent signaling in response to WNT
- Asymmetric localization of PCP proteins
- Signaling by Hedgehog
- degradation of AXIN
- Signaling by WNT in cancer
- PCP/CE pathway
- SMAD4 MH2 Domain Mutants in Cancer
- Adaptive Immune System
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|
| CANX and SLC4A1 |
calnexin |
solute carrier family 4 (anion exchanger), member 1 (Diego blood group) |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- O2/CO2 exchange in erythrocytes
- Erythrocytes take up carbon dioxide and release oxygen
- Transport of inorganic cations/anions and amino acids/oligopeptides
- Erythrocytes take up oxygen and release carbon dioxide
- SLC-mediated transmembrane transport
- Bicarbonate transporters
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|
| CANX and PMP22 |
calnexin |
peripheral myelin protein 22 |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|
| CANX and HTR3A |
calnexin |
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- Ion channel transport
- Ligand-gated ion channel transport
|
- Antihemophilic Factor
- Tenecteplase
|
- Ziprasidone
- Olanzapine
- Clozapine
- Mirtazapine
- Palonosetron
- Cisapride
- Procaine
- Rocuronium
- Dolasetron
- Granisetron
- Ondansetron
- Alosetron
- Memantine
- Chloroprocaine
- Tubocurarine
- Quetiapine
- Aripiprazole
- Tapentadol
|
|
|
| CANX and TRA |
calnexin |
T cell receptor alpha locus |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|
| CANX and GRIA1 |
calnexin |
glutamate receptor, ionotropic, AMPA 1 |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- Trafficking of GluR2-containing AMPA receptors
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- Activation of AMPA receptors
- Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
- Trafficking of AMPA receptors
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Unblocking of NMDA receptor, glutamate binding and activation
- Transmission across Chemical Synapses
|
- Antihemophilic Factor
- Tenecteplase
|
- L-Glutamic Acid
- Enflurane
- Isoflurane
- Methoxyflurane
- Desflurane
- Sevoflurane
- Perampanel
|
|
|
| CANX and GRIN1 |
calnexin |
glutamate receptor, ionotropic, N-methyl D-aspartate 1 |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- EPHB-mediated forward signaling
- Axon guidance
- Activation of NMDA receptor upon glutamate binding and postsynaptic events
- CREB phosphorylation through the activation of CaMKII
- EPH-Ephrin signaling
- CREB phosphorylation through the activation of Ras
- Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
- Unblocking of NMDA receptor, glutamate binding and activation
- Ras activation uopn Ca2+ infux through NMDA receptor
- Post NMDA receptor activation events
- Transmission across Chemical Synapses
|
- Antihemophilic Factor
- Tenecteplase
|
- L-Glutamic Acid
- Meperidine
- Orphenadrine
- Dcka, 5,7-Dichlorokynurenic Acid
- D-Serine
- Cycloleucine
- Milnacipran
- Agmatine
|
|
|
| CANX and LCT |
calnexin |
lactase |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- Myoclonic epilepsy of Lafora
- Digestion of dietary carbohydrate
- Glycogen storage diseases
- Metabolism of carbohydrates
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|
| CANX and TF |
calnexin |
transferrin |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- Response to elevated platelet cytosolic Ca2+
- Iron uptake and transport
- Platelet degranulation
- Transferrin endocytosis and recycling
- Platelet activation, signaling and aggregation
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|
| CANX and PDIA3 |
calnexin |
protein disulfide isomerase family A, member 3 |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Antigen processing-Cross presentation
- ER-Phagosome pathway
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|
| CANX and SLC2A1 |
calnexin |
solute carrier family 2 (facilitated glucose transporter), member 1 |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- Metabolism of vitamins and cofactors
- Defective CD320 causes methylmalonic aciduria
- Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF
- Integration of energy metabolism
- Defective BTD causes biotidinase deficiency
- Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
- Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
- SLC-mediated transmembrane transport
- Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE
- Defective AMN causes hereditary megaloblastic anemia 1
- Myoclonic epilepsy of Lafora
- Glycogen storage diseases
- Defects in cobalamin (B12) metabolism
- Defective GIF causes intrinsic factor deficiency
- Defective HLCS causes multiple carboxylase deficiency
- Defective MMAB causes methylmalonic aciduria type cblB
- Regulation of insulin secretion
- Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
- Vitamin C (ascorbate) metabolism
- Hexose transport
- Defective MMAA causes methylmalonic aciduria type cblA
- Defective CUBN causes hereditary megaloblastic anemia 1
- Metabolism of water-soluble vitamins and cofactors
- Defective MUT causes methylmalonic aciduria mut type
- Defects in biotin (Btn) metabolism
- Metabolism of carbohydrates
- Glucose transport
- Defective TCN2 causes hereditary megaloblastic anemia
- Defects in vitamin and cofactor metabolism
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|
| CANX and CD82 |
calnexin |
CD82 molecule |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
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|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|
| CANX and TG |
calnexin |
thyroglobulin |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|
| CANX and IFNGR1 |
calnexin |
interferon gamma receptor 1 |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- Interferon gamma signaling
- Interferon Signaling
- Cytokine Signaling in Immune system
- Regulation of IFNG signaling
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|
| CANX and SLC6A4 |
calnexin |
solute carrier family 6 (neurotransmitter transporter), member 4 |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
|
- Antihemophilic Factor
- Tenecteplase
|
- Fluvoxamine
- Phentermine
- Tramadol
- Citalopram
- Venlafaxine
- Atomoxetine
- Amitriptyline
- Protriptyline
- Methylphenidate
- Imipramine
- Fluoxetine
- Duloxetine
- Dextromethorphan
- Nortriptyline
- Amoxapine
- Fenfluramine
- Mazindol
- Trazodone
- Verapamil
- Paroxetine
- Trimipramine
- Minaprine
- Pseudoephedrine
- Cocaine
- Sertraline
- Sibutramine
- Chlorpheniramine
- Doxepin
- Nefazodone
- Desipramine
- Escitalopram
- Dexfenfluramine
- Clomipramine
- Ephedra
- MMDA
- 3,4-Methylenedioxymethamphetamine
- 4-Methoxyamphetamine
- Methamphetamine
- Zimelidine
- Amineptine
- Milnacipran
- Mianserin
- Tapentadol
- Desvenlafaxine
- Dexmethylphenidate
- Levomilnacipran
|
|
|
| CANX and LHCGR |
calnexin |
luteinizing hormone/choriogonadotropin receptor |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
- Signaling by GPCR
- GPCR downstream signaling
- G alpha (s) signalling events
- Class A/1 (Rhodopsin-like receptors)
- Hormone ligand-binding receptors
- Metabolic disorders of biological oxidation enzymes
- GPCR ligand binding
|
- Antihemophilic Factor
- Tenecteplase
|
- Goserelin
- Menotropins
- Lutropin alfa
- Cetrorelix
- Choriogonadotropin alfa
- Buserelin
|
|
|
| CANX and CD1D |
calnexin |
CD1d molecule |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|
| CANX and CD3D |
calnexin |
CD3d molecule, delta (CD3-TCR complex) |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- TCR signaling
- Downstream TCR signaling
- Generation of second messenger molecules
- Translocation of ZAP-70 to Immunological synapse
- Costimulation by the CD28 family
- PD-1 signaling
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
- Phosphorylation of CD3 and TCR zeta chains
- Adaptive Immune System
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|
| CANX and BCAP31 |
calnexin |
B-cell receptor-associated protein 31 |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
- Apoptotic cleavage of cellular proteins
- Programmed Cell Death
- Apoptotic execution phase
- Class I MHC mediated antigen processing & presentation
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Adaptive Immune System
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|
| CANX and FAM107A |
calnexin |
family with sequence similarity 107, member A |
- Diseases of glycosylation
- Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
- Defective MGAT2 causes MGAT2-CDG (CDG-2a)
- Defective ALG1 causes ALG1-CDG (CDG-1k)
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Virus Assembly and Release
- Defective MOGS causes MOGS-CDG (CDG-2b)
- Influenza Life Cycle
- Defective ALG9 causes ALG9-CDG (CDG-1l)
- Defective MAN1B1 causes MRT15
- MHC class II antigen presentation
- Class I MHC mediated antigen processing & presentation
- N-glycan trimming in the ER and Calnexin/Calreticulin cycle
- Assembly of Viral Components at the Budding Site
- Defective ALG11 causes ALG11-CDG (CDG-1p)
- Defective ALG2 causes ALG2-CDG (CDG-1i)
- Post-translational protein modification
- Defective ALG3 causes ALG3-CDG (CDG-1d)
- Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
- Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
- Influenza Infection
- Defective RFT1 causes RFT1-CDG (CDG-1n)
- Defective ALG6 causes ALG6-CDG (CDG-1c)
- Asparagine N-linked glycosylation
- Defective ALG8 causes ALG8-CDG (CDG-1h)
- Defective MPDU1 causes MPDU1-CDG (CDG-1f)
- Defective ALG12 causes ALG12-CDG (CDG-1g)
- Diseases associated with N-glycosylation of proteins
- Adaptive Immune System
- Calnexin/calreticulin cycle
|
|
- Antihemophilic Factor
- Tenecteplase
|
|
|
|