IL32 and C1QB

Number of citations of the paper that reports this interaction (PubMedID 25178676)
0

Data Source:
BioGRID (two hybrid)

		IL32	C1QB
Description		interleukin 32	complement C1q B chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Membrane	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Surface Extracellular Matrix Synapse Complement Component C1q Complex Blood Microparticle Postsynapse Symbiont Cell Surface
	Molecular Function	Cytokine Activity Protein Binding	Phosphatidylserine Binding IgM Binding Protein Binding IgG Binding
	Biological Process	Defense Response Immune Response Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Type III Interferon Production Negative Regulation Of Viral Life Cycle	Immune System Process Complement Activation Complement Activation, Classical Pathway Innate Immune Response Synapse Pruning
Pathways		Other interleukin signaling RAC3 GTPase cycle	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs			Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) HIV-1 susceptibility ( 22174851) Liver enzyme levels (alanine transaminase) ( 33972514)
Interacting Genes		11 interacting genes: C1QB HSPA8 KPNA5 NDN NQO2 PRTN3 RHBDD2 RPL4 SNRNP70 TUT1 ZFPM2	11 interacting genes: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA UBQLN2
Entrez ID		9235	713
HPRD ID		09346	00394
Ensembl ID		ENSG00000008517	ENSG00000173369
Uniprot IDs		C6GKH1 G3LU47 P24001	A0A024RAB9 D6R934 P02746
PDB IDs			1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V 9C9L 9C9U
Enriched GO Terms of Interacting Partners?			Complement Component C1 Complex Immune Response Defense Response To Other Organism Defense Response To Symbiont Defense Response Symbiont Cell Surface Humoral Immune Response Complement Component C1q Complex Response To Other Organism Innate Immune Response Complement Activation, Classical Pathway Extrinsic Component Of Presynaptic Membrane Immune System Process IgM Binding Response To External Biotic Stimulus Complement Activation Extracellular Region Response To Fungus Response To Stress Extrinsic Component Of Postsynaptic Membrane Synapse Pruning IgG Binding Positive Regulation Of Immune Response Opsonization Blood Microparticle Killing Of Cells Of Another Organism Immune Effector Process Activation Of Immune Response Extracellular Matrix Extracellular Space Positive Regulation Of Focal Adhesion Assembly Killing By Host Of Symbiont Cells Regulation Of Immune Response Cell Killing Positive Regulation Of Immune System Process Biological Process Involved In Interaction With Symbiont Cell Surface Defense Response To Fungus Phosphatidylserine Binding Skeletal Muscle Hypertrophy Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cell-matrix Adhesion Regulation Of Focal Adhesion Assembly Collagen Trimer Negative Regulation Of Viral Process Regulation Of Cell-substrate Junction Organization Negative Regulation By Host Of Viral Glycoprotein Metabolic Process (1->3)-beta-D-glucan Binding NF-kappaB P50/p65 Complex Positive Regulation Of Type III Interferon Production See more
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