ZNF177 and ARHGAP21

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ZNF177	ARHGAP21
Description		zinc finger protein 177	Rho GTPase activating protein 21
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Blood Microparticle	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Cell Junction Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Anchoring Junction
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	GTPase Activator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Golgi Organization Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Golgi Localization Establishment Of Golgi Localization Maintenance Of Golgi Location Organelle Transport Along Microtubule
Pathways			RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND3 GTPase cycle
Drugs
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Diisocyanate-induced asthma ( 25918132) Immature fraction of reticulocytes ( 32888494) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Optic disc area ( 31798171) Optic disc size ( 31809533) Stress sensitivity (neuroticism score x major depressive disorder status interaction) ( 30571770) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		20 interacting genes: ARHGAP21 BOLA2 BOLA2B CIB3 CSNK2A1 CT55 EXOC8 LMO1 MID2 MLH1 PMVK PRKAB2 PRKAR1B PSMB1 RHOU SLC37A3 SNAP25 SNAPC5 TRAF4 ZGPAT	9 interacting genes: ARF1 EEF1D PCNT PTK2B RHOA SP1 TULP3 VPS26C ZNF177
Entrez ID		7730	57584
HPRD ID		03175	06445
Ensembl ID		ENSG00000188629	ENSG00000107863
Uniprot IDs		Q13360	A0A805TBS0 Q5T5U3
PDB IDs			2DHJ 2J59 2YUY
Enriched GO Terms of Interacting Partners?		Iron-sulfur Cluster Assembly Complex [2Fe-2S] Cluster Assembly	Mitotic Cytokinetic Process Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Cleavage Furrow Ingression Membrane Invagination Regulation Of Supramolecular Fiber Organization Cytokinetic Process Mitotic Cleavage Furrow Ingression Aortic Valve Formation Regulation Of Endothelial Cell Migration Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Lymphocyte Migration Positive Regulation Of Vascular Associated Smooth Muscle Contraction Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Positive Regulation Of Lymphocyte Migration Skeletal Muscle Satellite Cell Migration Neurotransmitter Receptor Regulator Activity Positive Regulation Of B Cell Chemotaxis Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Cellular Response To Wortmannin Response To Wortmannin Bronchus Morphogenesis Ciliary Base Mitotic Spindle Organization Positive Regulation Of Mononuclear Cell Migration Focal Adhesion Beta Selection Intraciliary Transport Particle A Binding See more
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