UROD and CHD3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		UROD	CHD3
Gene Name		uroporphyrinogen decarboxylase	chromodomain helicase DNA binding protein 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome NuRD Complex Intermediate Filament Cytoskeleton
	Molecular Function	Uroporphyrinogen Decarboxylase Activity	DNA Binding ATP-dependent DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Poly(A) RNA Binding
	Biological Process	Porphyrin-containing Compound Metabolic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Small Molecule Metabolic Process	Chromatin Organization Chromatin Assembly Or Disassembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Spindle Organization Chromatin Modification DNA Duplex Unwinding Centrosome Organization
Pathways		Heme biosynthesis Metabolism of porphyrins	Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance
Drugs		Coproporphyrin I Coproporphyrin Iii
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CHD3 EGFR FAF1 FAM84B HMGXB4 VIM	90 interactors: ACTR1B ADH5 AIMP2 ATPIF1 BARD1 BCL6 BHLHE40 C4orf17 CASP6 CASP8 CPE CRCT1 CREB1 CSTF2 CTBP1 CTTN FABP4 FAM134A FBP2 FUBP1 GADD45A GIT1 GPS2 GSK3B HABP4 HSD17B10 HSPH1 HTT IK IKZF1 IKZF3 IMMT IVNS1ABP KIF15 KPNA2 KPNB1 LRIF1 LUC7L2 MAFG MAN2A2 MYB NEFL NR1H2 NR4A1 PAICS PCMT1 PIAS4 PLK4 PRG2 PRPF40A PSME1 PTN PTPRS PUF60 RAD51 RGS2 RIF1 RPL29 SAFB SAT1 SATB1 SDCCAG3 SERBP1 SERF2 SGSM2 SIRT6 SKIL SLC27A6 SRRT SUMO1 SUMO2 TAL1 TCERG1 THOC7 TNFRSF14 TNNT1 TP53 TP73 TRIM28 TSC22D1 TSPAN6 TTR TXNDC9 UBA3 UBE2I UROD VIM XRCC4 YAE1D1 ZHX1
Entrez ID		7389	1107
HPRD ID		01441	09071
Ensembl ID		ENSG00000126088	ENSG00000170004
Uniprot IDs		P06132	B3KWV4 Q12873 Q2TAZ1
PDB IDs		1JPH 1JPI 1JPK 1R3Q 1R3R 1R3S 1R3T 1R3V 1R3W 1R3Y 1URO 2Q6Z 2Q71 3GVQ 3GVR 3GVV 3GVW 3GW0 3GW3
Enriched GO Terms of Interacting Partners?		Astrocyte Development Astrocyte Differentiation Glial Cell Development Alkanesulfonate Metabolic Process Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Regulation Of Protein Import Into Nucleus Glial Cell Differentiation Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Activation Of Phospholipase A2 Activity Negative Regulation Of Signal Transduction Positive Regulation Of Phospholipase A2 Activity Gliogenesis Negative Regulation Of Signaling Response To Cobalamin Response To UV-A Regulation Of Intracellular Protein Transport Cytoplasmic Sequestering Of NF-kappaB Response To Hydroxyisoflavone Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Bergmann Glial Cell Differentiation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Catenin Import Into Nucleus Regulation Of Phospholipase A2 Activity Regulation Of Protein Catabolic Process Regulation Of Superoxide Anion Generation Magnesium Ion Homeostasis Regulation Of Metabolic Process Regulation Of Intracellular Transport Intermediate Filament Organization Negative Regulation Of NF-kappaB Import Into Nucleus Cellular Response To Estradiol Stimulus Lens Fiber Cell Development Protein Insertion Into Membrane Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Catenin Import Into Nucleus Cellular Response To Epidermal Growth Factor Stimulus Cytoplasmic Sequestering Of Protein	Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process RNA Metabolic Process RNA Biosynthetic Process Transcription, DNA-templated Negative Regulation Of Gene Expression Viral Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Biosynthetic Process Protein Sumoylation Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cell Death Regulation Of Cellular Process Positive Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Positive Regulation Of Organelle Organization Regulation Of Cell Differentiation Negative Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Regulation Of Gene Expression Positive Regulation Of Programmed Cell Death B Cell Activation Cellular Process Negative Regulation Of Cell Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Death Programmed Cell Death Cell Differentiation Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Death Negative Regulation Of Apoptotic Process Death Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Immune System Process
Tagcloud ?		affinities arg37 arg41 arg803 asp863 attempts backbone candidates catalytic cmu computational decarboxylase edu egfr evolving head her2 http modulate neck radiotherapy residues taiwan tcm thr854 thr862 traditional tw uroporphyrinogen	ancestor animal arabidopsis atp codes deacetylation exhibits exists mi monomer mononucleosomes multisubunit naked nurd pickle planta promotes remodeler remodelers remodeling restrict retain share ssdna subfamily thaliana trimethylation ubiquitous
Tagcloud (Difference) ?		affinities arg37 arg41 arg803 asp863 attempts backbone candidates catalytic cmu computational decarboxylase edu egfr evolving head her2 http modulate neck radiotherapy residues taiwan tcm thr854 thr862 traditional tw uroporphyrinogen	ancestor animal arabidopsis atp codes deacetylation exhibits exists mi monomer mononucleosomes multisubunit naked nurd pickle planta promotes remodeler remodelers remodeling restrict retain share ssdna subfamily thaliana trimethylation ubiquitous
Tagcloud (Intersection) ?