SKP2 and CKS1B

Number of citations of the paper that reports this interaction (PMID 11231585)
106

Data Source:
HPRD (in vitro, in vivo)

		SKP2	CKS1B
Gene Name		S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	CDC28 protein kinase regulatory subunit 1B
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Aggresome SCF Ubiquitin Ligase Complex	Nucleoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Cell Proliferation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Regulation Of Cell Cycle Cellular Response To Cell-matrix Adhesion	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cell Proliferation Cell Division
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation G1 Phase S Phase Cyclin E associated events during G1/S transition APC/C-mediated degradation of cell cycle proteins Cell Cycle, Mitotic SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 G1/S Transition Regulation of mitotic cell cycle Class I MHC mediated antigen processing & presentation Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases Adaptive Immune System	Cyclin D associated events in G1 SCF(Skp2)-mediated degradation of p27/p21 G1/S Transition G1 Phase Cyclin E associated events during G1/S transition SCF(Skp2)-mediated degradation of p27/p21 S Phase Cyclin A:Cdk2-associated events at S phase entry Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		54 interactors: AKT1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDH1 CDK2 CDK9 CDKN1A CDKN1B CDKN1C CDT1 CEBPA CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 ESR1 FZR1 GPS1 KPNA1 KPNA6 MYB MYBL2 MYC NLK ORC1 PFDN1 PIM1 PSMD9 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SMAD4 TAL1 TCF3 TRIM21 UBB VHL WEE1 YWHAB YY1	34 interactors: ARID5A CCNA1 CCNA2 CCNB2 CDC27 CDC37 CDK1 CDK2 CDKN1B CDX4 CKS1BP7 CKS2 CUL1 DUSP1 HSP90AA1 IKZF1 KIAA0368 KRTAP10-9 KRTAP5-9 LDHB MEOX1 MIPOL1 PSMD9 REL ROPN1 SEPT3 SKP1 SKP2 SPERT SSBP1 SUMO1P1 TCF4 TRIM27 XIAP
Entrez ID		6502	1163
HPRD ID		03256	00299
Ensembl ID		ENSG00000145604	ENSG00000173207
Uniprot IDs		Q13309	P61024 Q5T178
PDB IDs		1FQV 1FS1 1FS2 1LDK 2ASS 2AST	1BUH 1DKS 1DKT 2ASS 2AST
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cell Cycle Cell Cycle Cell Cycle Process Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Positive Regulation Of Cell Cycle Regulation Of Cell Proliferation DNA Damage Checkpoint Cellular Response To DNA Damage Stimulus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Gene Expression Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stress Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Catalytic Activity Negative Regulation Of Transferase Activity DNA Metabolic Process Cellular Protein Modification Process	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle G2/M Transition Of Mitotic Cell Cycle Cell Cycle Process Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Cell Division Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Mitotic Cell Cycle Checkpoint Regulation Of Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Mitotic DNA Damage Checkpoint Regulation Of Protein Kinase Activity Mitotic DNA Integrity Checkpoint Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Kinase Activity Cellular Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Cell Cycle Checkpoint Regulation Of Cell Cycle Phase Transition Protein Catabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1	axis biomarker cascade chemoresistance chemoresistant discoveries doi drive escape exerts gained immunoinhibitory inversely l1 l1highdrug mechanistic microrna mimic mir mt nsclc pd platinum programmed promotion sensitizes stat3 tumorigenicity worse
Tagcloud (Difference) ?		antisense box cdc53 cdk2 cip1 complex cul cullin deregulation e3 g1 hallmark kip1 ligase lived member oligodeoxynucleotides oligonucleotides p19 p21 p27 p45 proteolysis raises scf skp1 transformed ubiquitin waf1	axis biomarker cascade chemoresistance chemoresistant discoveries doi drive escape exerts gained immunoinhibitory inversely l1 l1highdrug mechanistic microrna mimic mir mt nsclc pd platinum programmed promotion sensitizes stat3 tumorigenicity worse
Tagcloud (Intersection) ?