AIM2

Gene Name		absent in melanoma 2
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol AIM2 Inflammasome Complex
	Molecular Function	Double-stranded DNA Binding Protein Binding Identical Protein Binding
	Biological Process	Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Apoptotic Process Inflammatory Response Immune Response Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Oligomerization Positive Regulation Of Interleukin-1 Beta Production Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Interferon-beta Cellular Response To Drug Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Innate Immune Response Interleukin-1 Beta Secretion Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Pyroptosis Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways		Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways The AIM2 inflammasome Innate Immune System
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-protein Interactions		1 interactors: APPBP2
Entrez ID		9447
HPRD ID		05202
Ensembl ID		ENSG00000163568
Uniprot IDs		O14862
PDB IDs		3RN2 3RN5 3VD8
Enriched GO Terms of Interacting Partners?
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