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P4HA2

Gene Name prolyl 4-hydroxylase, alpha polypeptide II
Image No pdb structure
Gene Ontology Annotations Cellular Component
  • Nucleus
  • Cytoplasm
  • Endoplasmic Reticulum
  • Endoplasmic Reticulum Lumen
  • Procollagen-proline 4-dioxygenase Complex
  • Intracellular Membrane-bounded Organelle
Molecular Function
  • Procollagen-proline 4-dioxygenase Activity
  • Iron Ion Binding
  • Electron Carrier Activity
  • Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen
  • L-ascorbic Acid Binding
Biological Process
  • Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
  • Oxidation-reduction Process
Pathways
Drugs
Diseases
GWAS
  • Crohn's disease ( 22412388)
Protein-protein Interactions 3 interactors: FHL3 P4HB PRRC2A
Entrez ID 8974
HPRD ID 11862
Ensembl ID ENSG00000072682
Uniprot IDs O15460 Q05DA4
PDB IDs
Enriched GO Terms of Interacting Partners?
  • Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
  • 4-hydroxyproline Metabolic Process
  • Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
  • Peptidyl-proline Hydroxylation
  • Protein Hydroxylation
  • Regulation Of Cellular Response To Oxidative Stress
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© Madhavi K. Ganapathiraju 2012-2025