HRK

Gene Name		harakiri, BCL2 interacting protein
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Integral Component Of Membrane
	Molecular Function	Protein Binding
	Biological Process	Apoptotic Process Positive Regulation Of Protein Homooligomerization Positive Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (age of onset) ( 22005931) Brain structure ( 22504417) Hippocampal volume ( 22504421)
Protein-protein Interactions		7 interactors: BAD BCL2 BCL2A1 BCL2L1 BCL2L2 C1QBP MCL1
Entrez ID		8739
HPRD ID		04581
Ensembl ID
Uniprot IDs		O00198
PDB IDs		2L58 2L5B
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Negative Regulation Of Intracellular Signal Transduction Programmed Cell Death Cell Death Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Negative Regulation Of Anoikis Regulation Of Mitochondrion Organization Regulation Of Anoikis Regulation Of Intracellular Signal Transduction Cellular Response To DNA Damage Stimulus Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Release Of Cytochrome C From Mitochondria Negative Regulation Of Signal Transduction Suppression By Virus Of Host Apoptotic Process Regulation Of Mitochondrial Membrane Potential Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Signaling Regulation Of Membrane Permeability Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Signal Transduction Cellular Response To Stress Positive Regulation Of Mitochondrion Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrial Membrane Organization Cellular Process Regulating Host Cell Cycle In Response To Virus Regulation Of Signaling Regulation Of Neuron Death Positive Regulation Of Intracellular Signal Transduction Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mitochondrion Organization Regulation Of Autophagy
Tagcloud ?		a280 acidic adsorptions ahraa amidase amidases amidolysis aprotinin arginine bean bis column daltons differing egta elution elutions ethylenglycol ethylether kallikrein lbti leu lima named pna tentatively tetraacetic trypsin val