HELZ2

Gene Name		helicase with zinc finger 2, transcriptional coactivator
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Membrane
	Molecular Function	DNA Binding Helicase Activity Protein Binding ATP Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: PPARA PPARG
Entrez ID		85441
HPRD ID		11459
Ensembl ID		ENSG00000130589
Uniprot IDs		Q9BYK8
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Sequestering Of Triglyceride Negative Regulation Of Cholesterol Storage Positive Regulation Of Fatty Acid Oxidation Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process Negative Regulation Of Lipid Storage Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Oxidation Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Lipid Storage Fatty Acid Transport Regulation Of Fatty Acid Metabolic Process Regulation Of Lipid Transport Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Monocarboxylic Acid Transport Hormone-mediated Signaling Pathway Response To Alkaloid Transcription Initiation From RNA Polymerase II Promoter Regulation Of Blood Pressure Cellular Response To Steroid Hormone Stimulus Intracellular Receptor Signaling Pathway Response To Metformin Response To Diuretic Low-density Lipoprotein Particle Receptor Biosynthetic Process Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Pancreatic Stellate Cell Proliferation DNA-templated Transcription, Initiation Response To Insulin Regulation Of Lipid Metabolic Process Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Vitamin E Regulation Of Cholesterol Transporter Activity Lipid Transport Carboxylic Acid Transport Organic Acid Transport Blood Circulation Fatty Acid Metabolic Process Lipid Localization Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Nutrient Levels Organic Anion Transport Response To Peptide Hormone Negative Regulation Of Collagen Biosynthetic Process Response To Extracellular Stimulus Response To Steroid Hormone Response To Peptide Regulation Of Cellular Ketone Metabolic Process
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