TCF7L1

Gene Name		transcription factor 7-like 1 (T-cell specific, HMG-box)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Beta-catenin Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Brain Development Anterior/posterior Axis Specification, Embryo Regulation Of Wnt Signaling Pathway Somatic Stem Cell Maintenance Skin Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Axial Mesoderm Morphogenesis Generation Of Neurons Canonical Wnt Signaling Pathway Regulation Of Stem Cell Maintenance
Pathways		APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes beta-catenin independent WNT signaling deletions in the AMER1 gene destabilize the destruction complex Ca2+ pathway TCF dependent signaling in response to WNT AMER1 mutants destabilize the destruction complex deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: CTNNB1
Entrez ID		83439
HPRD ID		06874
Ensembl ID		ENSG00000152284
Uniprot IDs		Q9HCS4
PDB IDs
Enriched GO Terms of Interacting Partners?		Schwann Cell Proliferation Negative Regulation Of Mitotic Cell Cycle, Embryonic Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Glial Cell Fate Determination Oviduct Development Regulation Of Centriole-centriole Cohesion Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Positive Regulation Of Determination Of Dorsal Identity Embryonic Skeletal Limb Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Lung Induction Central Nervous System Vasculogenesis Trachea Formation Cellular Response To Indole-3-methanol Regulation Of Centromeric Sister Chromatid Cohesion Renal Vesicle Formation Regulation Of Mitotic Cell Cycle, Embryonic Negative Regulation Of Protein Sumoylation Positive Regulation Of Branching Involved In Lung Morphogenesis Regulation Of Secondary Heart Field Cardioblast Proliferation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Branching Involved In Lung Morphogenesis Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Fungiform Papilla Formation Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Establishment Of Blood-brain Barrier Fungiform Papilla Morphogenesis Glial Cell Proliferation Metanephric Renal Vesicle Morphogenesis Endothelial Tube Morphogenesis Renal Vesicle Morphogenesis Sympathetic Ganglion Development Endodermal Cell Fate Commitment Fungiform Papilla Development Regulation Of Sister Chromatid Cohesion Neural Plate Development Positive Regulation Of Endothelial Cell Differentiation Mesenchymal Cell Proliferation Lung-associated Mesenchyme Development Mesenchymal To Epithelial Transition Epithelial Cell Differentiation Involved In Prostate Gland Development Trachea Morphogenesis Positive Regulation Of Glycoprotein Biosynthetic Process Genitalia Morphogenesis
Tagcloud ?		aggressive buds controlling differentiated disrupts dramatically duct ductal es gland identity initiate lef link mammary mammosphere preferentially promotes renewal represses repressing responsive sphere subset tcf3 thought tumorigenicity wnt