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TP73
Gene Name
tumor protein p73
Image
Gene Ontology Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Factor Complex
Golgi Apparatus
Cytosol
Cell Junction
Intracellular Membrane-bounded Organelle
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
P53 Binding
Chromatin Binding
Damaged DNA Binding
Double-stranded DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Identical Protein Binding
Transcription Regulatory Region DNA Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Activation Of MAPK Activity
Kidney Development
Release Of Cytochrome C From Mitochondria
Mismatch Repair
Transcription From RNA Polymerase II Promoter
Inflammatory Response
Cellular Response To DNA Damage Stimulus
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Cell Cycle Arrest
Regulation Of Mitotic Cell Cycle
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Post-embryonic Development
Response To X-ray
Response To Organonitrogen Compound
Response To Gamma Radiation
Regulation Of Gene Expression
Hippocampus Development
Mitotic G1 DNA Damage Checkpoint
Cerebrospinal Fluid Secretion
Cellular Response To UV
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Negative Regulation Of JUN Kinase Activity
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Cell Size
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Digestive Tract Morphogenesis
Neuron Development
Positive Regulation Of Oligodendrocyte Differentiation
Protein Tetramerization
Negative Regulation Of Cardiac Muscle Cell Proliferation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways
Drugs
Diseases
GWAS
Visceral adipose tissue adjusted for BMI (
22589738
)
Visceral adipose tissue/subcutaneous adipose tissue ratio (
22589738
)
Visceral fat (
22589738
)
Protein-protein Interactions
50 interactors:
ABL1
AURKA
BIN1
BUB1B
CABLES1
CCNB1
CCND1
CCNE1
CDK1
CDK2
CEBPZ
CHD3
CREBBP
DAXX
EP300
FBXO45
GNB2L1
HECW2
HIPK2
HIPK3
HMGB1
HRAS
IKBKB
ITCH
KAT2B
MAPK8
MDM2
MDM4
MYC
NEDD4
NFYB
PFDN5
PIAS1
PIN1
PML
PPP1R13B
RANBP9
RBX1
RCHY1
SMAD2
SMAD3
SUMO1
TDG
TP53
TP63
UBE2I
WT1
WWOX
XPO1
YAP1
Entrez ID
7161
HPRD ID
03587
Ensembl ID
ENSG00000078900
Uniprot IDs
C9J521
O15350
PDB IDs
1COK
1DXS
2KBY
2WQI
2WQJ
2WTT
2XWC
3VD0
3VD1
3VD2
4A63
4G82
4G83
4GUQ
Enriched GO Terms of Interacting Partners
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Regulation Of Protein Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Cellular Metabolic Process
Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Cell Cycle
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Transcription, DNA-templated
Apoptotic Process
Programmed Cell Death
Negative Regulation Of Cell Cycle
Cell Cycle Process
Regulation Of Signal Transduction
Cell Death
Cellular Response To Stress
Death
Positive Regulation Of Gene Expression
Regulation Of Protein Catabolic Process
Regulation Of Apoptotic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Cell Death
Regulation Of Signaling
Positive Regulation Of Protein Metabolic Process
Viral Process
Cellular Response To DNA Damage Stimulus
Signal Transduction By P53 Class Mediator
Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle
Response To Stress
Mitotic Cell Cycle Process
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cell Death
Cellular Response To Organic Substance
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Proteolysis
Negative Regulation Of Mitotic Cell Cycle
Ubiquitin-dependent Protein Catabolic Process
Tagcloud
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acidic
amylin
calcitonin
calcr
causally
deltan
glycolysis
iapp
implement
interplay
isoforms
lymphomas
manipulating
p63
pramlintide
ramp3
reactivation
reprogramming
resemble
suppressive
ta
tap63
tap73
therapeutically
thymic
tp53
tp63
tumours