HMGB3

Gene Name		high mobility group box 3
Image
Gene Ontology Annotations	Cellular Component	Nucleus Chromosome
	Molecular Function	Chromatin Binding Double-stranded DNA Binding DNA Binding, Bending Poly(A) RNA Binding
	Biological Process	DNA Recombination Chromatin Remodeling Regulation Of Transcription, DNA-templated Multicellular Organismal Development Negative Regulation Of B Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: HMGA1 SDCBP TERF2IP
Entrez ID		3149
HPRD ID		02181
Ensembl ID		ENSG00000029993
Uniprot IDs		O15347
PDB IDs		2EQZ 2YQI
Enriched GO Terms of Interacting Partners?		Negative Regulation Of DNA Recombination At Telomere Oncogene-induced Cell Senescence Senescence-associated Heterochromatin Focus Assembly DNA Replication Positive Regulation Of Extracellular Vesicular Exosome Assembly Positive Regulation Of Cellular Senescence Protection From Non-homologous End Joining At Telomere Regulation Of Extracellular Vesicular Exosome Assembly Telomere Capping Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Chromatin Silencing Establishment Of Integrated Proviral Latency Positive Regulation Of Cell Aging Establishment Of Viral Latency Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Heterochromatin Assembly Substrate-dependent Cell Migration, Cell Extension Regulation Of Double-strand Break Repair Via Homologous Recombination DNA Unwinding Involved In DNA Replication Nucleosome Disassembly Heterochromatin Organization Positive Regulation Of Gene Expression, Epigenetic Regulation Of Telomere Maintenance Organelle Organization RNA-dependent DNA Replication Regulation Of Gene Silencing Negative Regulation Of DNA Recombination Regulation Of Cellular Senescence Positive Regulation Of Organelle Assembly Regulation Of Double-strand Break Repair Positive Regulation Of Intracellular Signal Transduction Protein Localization To Chromosome Cellular Senescence Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomere Lengthening Regulation Of Organelle Organization Substrate-dependent Cell Migration Chromosome Organization DNA Metabolic Process Positive Regulation Of Exocytosis Regulation Of DNA Repair Base-excision Repair Positive Regulation Of Signal Transduction Regulation Of DNA Recombination Cell Aging Cellular Protein Localization Telomere Maintenance
Tagcloud ?		5p calr cd34 cd41 cdc42 downregulation dysregulation eg fgr gathering hyperplasia integrative jarid2 lcn2 megakaryocyte microrna mirna mk mks mpl myelofibrosis neoplasm nr4a3 olfm4 pathophysiology pmf precursors strongest unveiled