GSTZ1

Gene Name		glutathione S-transferase zeta 1
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Gene Ontology Annotations	Cellular Component	Mitochondrion Cytosol
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Maleylacetoacetate Isomerase Activity Protein Homodimerization Activity
	Biological Process	L-phenylalanine Catabolic Process Tyrosine Catabolic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process Glutathione Derivative Biosynthetic Process
Pathways		Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Phenylalanine and tyrosine catabolism Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Metabolism of amino acids and derivatives Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs		Glutathione 1,4-Dithiothreitol
Diseases
GWAS
Protein-protein Interactions		2 interactors: GSS PPP1CC
Entrez ID		2954
HPRD ID		04785
Ensembl ID		ENSG00000100577
Uniprot IDs		G3V4T6 O43708
PDB IDs		1FW1
Enriched GO Terms of Interacting Partners?		Triglyceride Catabolic Process Entrainment Of Circadian Clock By Photoperiod Glutathione Biosynthetic Process Glutathione Derivative Biosynthetic Process Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process Peptide Biosynthetic Process Response To Cadmium Ion Glycogen Metabolic Process Glutathione Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To External Stimulus Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Triglyceride Metabolic Process Regulation Of Circadian Rhythm Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Response To Amino Acid Small Molecule Metabolic Process Response To Tumor Necrosis Factor Response To Organic Substance Energy Reserve Metabolic Process Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Response To Xenobiotic Stimulus Cellular Lipid Catabolic Process Peptide Metabolic Process Circadian Rhythm Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Cellular Carbohydrate Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Lipid Catabolic Process Cellular Modified Amino Acid Metabolic Process Protein Dephosphorylation Cellular Amide Metabolic Process
Tagcloud ?		abolishes acidosis alter australian biotransformation catabolic catalyses converts dca dichloroacetic egr1 extending fumarylacetoacetate glutathione halo haplotypes homeodomain isomerization lactic maleylacetoacetate myb pharmacokinetics polymorphisms prx2 snp snps therapeutically transferase zeta