SETD2

Gene Name		SET domain containing 2
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Chromosome
	Molecular Function	Protein Binding Histone-lysine N-methyltransferase Activity
	Biological Process	Angiogenesis Morphogenesis Of A Branching Structure Neural Tube Closure Mismatch Repair Chromatin Organization Regulation Of Transcription, DNA-templated Transcription Elongation From RNA Polymerase II Promoter Regulation Of MRNA Export From Nucleus Forebrain Development Nucleosome Organization Cell Migration Involved In Vasculogenesis Mesoderm Morphogenesis Embryonic Cranial Skeleton Morphogenesis Stem Cell Development Pericardium Development Embryonic Placenta Morphogenesis Coronary Vasculature Morphogenesis Histone H3-K36 Trimethylation
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines
Drugs
Diseases
GWAS
Protein-protein Interactions		8 interactors: ATXN1 CIC HIST1H3A HIST3H3 HTT POLR2A SIAH2 SMAD3
Entrez ID		29072
HPRD ID		11043
Ensembl ID		ENSG00000181555
Uniprot IDs		Q9BYW2
PDB IDs		2A7O 4FMU 4H12
Enriched GO Terms of Interacting Partners?		Paraxial Mesoderm Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Paraxial Mesoderm Development Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Nitrogen Compound Metabolic Process Lung Alveolus Development Visual Learning Visual Behavior Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Associative Learning Neural Plate Formation Positive Regulation Of Transforming Growth Factor Beta3 Production Mesoderm Formation Negative Regulation Of Signaling Mesoderm Morphogenesis Regulation Of Phosphatase Activity Gene Silencing Negative Regulation Of Gene Expression Serotonin Uptake Transcription, RNA-templated Lactate Biosynthetic Process From Pyruvate RNA Processing Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Dephosphorylation Formation Of Primary Germ Layer Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of RNA Metabolic Process Learning Mesoderm Development Positive Regulation Of Gene Expression Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Phosphatase Type 2A Activity Evasion Or Tolerance Of Host Defenses By Virus Nucleobase-containing Compound Metabolic Process Cellular Metabolic Process Tube Development Quinolinate Biosynthetic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Synaptic Transmission, Dopaminergic Cellular Aromatic Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Cell Differentiation
Tagcloud ?		cpg cues de dense dnmt1 dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects transcribed