CBX6

Description		chromobox 6
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GO Annotations	Cellular Component	Chromatin Heterochromatin Nucleus Nucleoplasm Chromosome Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Single-stranded RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization
Pathways		Oxidative Stress Induced Senescence RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Bladder cancer ( 20972438 24163127) Plateletcrit ( 32888494)
Interacting Genes		7 interacting genes: H3-3A H3C1 H3C14 HOXC9 PCGF2 PCGF6 RNF2
Entrez ID		23466
HPRD ID		13005
Ensembl ID		ENSG00000183741
Uniprot IDs		B0QXZ6 O95503
PDB IDs		3GV6 3I90
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling PRC1 Complex Chromatin Organization PcG Protein Complex Sex Chromatin Structural Constituent Of Chromatin Nucleosome Assembly Nucleosome Nucleosome Organization Nucleoplasm Protein-DNA Complex Assembly Chromosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Epigenetic Regulation Of Gene Expression Gene Expression Embryonic Skeletal System Development Protein Heterodimerization Activity Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Pattern Specification Process DNA Binding Chromatin Embryonic Skeletal System Morphogenesis Embryonic Morphogenesis Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Binding Nucleus Skeletal System Morphogenesis Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Telomere Organization Embryonic Organ Morphogenesis Negative Regulation Of Macromolecule Metabolic Process RING-like Zinc Finger Domain Binding Negative Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Condensation Histone H2AK119 Ubiquitin Ligase Activity Negative Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Anterior/posterior Pattern Specification Pericentric Heterochromatin Formation Regulation Of Centromere Complex Assembly Skeletal System Development Germ Cell Development Barr Body See more
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