DOLK

Gene Name		dolichol kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Dolichol Kinase Activity
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Phosphorylation Protein N-linked Glycosylation Via Asparagine Dolichyl Monophosphate Biosynthetic Process Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Synthesis of Dolichyl-phosphate Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: EDA
Entrez ID		22845
HPRD ID		15525
Ensembl ID		ENSG00000175283
Uniprot IDs		Q9UPQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Trachea Gland Development Salivary Gland Cavitation Hair Follicle Placode Formation Positive Regulation Of NF-kappaB Import Into Nucleus Ectoderm Development Trachea Development Positive Regulation Of Transcription Factor Import Into Nucleus Regulation Of NF-kappaB Import Into Nucleus Salivary Gland Morphogenesis Salivary Gland Development Exocrine System Development Regulation Of Transcription Factor Import Into Nucleus Hair Follicle Development Positive Regulation Of Protein Import Into Nucleus Hair Cycle Process Hair Cycle Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Pigmentation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Odontogenesis Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Intracellular Protein Transport Gland Morphogenesis Tube Formation Regulation Of Protein Import Into Nucleus Cell-matrix Adhesion Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell-substrate Adhesion Regulation Of Canonical Wnt Signaling Pathway Skin Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Epidermis Development Respiratory System Development Regulation Of Wnt Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Transport Tube Morphogenesis Regulation Of Intracellular Transport Gland Development Regulation Of Protein Transport
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