RAB12

Description		RAB12, member RAS oncogene family
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Autophagosome Golgi Apparatus Cytosol Plasma Membrane Synaptic Vesicle Membrane Trans-Golgi Network Transport Vesicle Cytoplasmic Vesicle Recycling Endosome Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Metal Ion Binding
	Biological Process	Exocytosis Autophagy Endosome To Lysosome Transport Protein Transport Protein Catabolic Process Endocytic Recycling Rab Protein Signal Transduction
Pathways		RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		1 interacting genes: OPTN
Entrez ID		201475
HPRD ID		18749
Ensembl ID		ENSG00000206418
Uniprot IDs		A0A3B3ITT1 Q6IQ22
PDB IDs		2IL1 8VH4 8VH5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Xenophagy Negative Regulation Of Receptor Recycling Golgi Ribbon Formation Type 2 Mitophagy Cellular Response To Unfolded Protein Protein Localization To Golgi Apparatus Cellular Response To Topologically Incorrect Protein K63-linked Polyubiquitin Modification-dependent Protein Binding Regulation Of Receptor Recycling Golgi To Plasma Membrane Protein Transport Polyubiquitin Modification-dependent Protein Binding Mitophagy Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Negative Regulation Of Canonical NF-kappaB Signal Transduction Autophagosome Response To Unfolded Protein Positive Regulation Of Macroautophagy Post-Golgi Vesicle-mediated Transport Defense Response To Gram-negative Bacterium Autophagy Of Mitochondrion Recycling Endosome Membrane Golgi Organization Vesicle-mediated Transport To The Plasma Membrane Recycling Endosome Macroautophagy Positive Regulation Of Autophagy Protein Localization To Plasma Membrane Trans-Golgi Network Regulation Of Macroautophagy Establishment Of Protein Localization To Membrane Protein-macromolecule Adaptor Activity Protein Localization To Cell Periphery See more
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