DHFRL1

Gene Name		dihydrofolate reductase-like 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	MRNA Binding Dihydrofolate Reductase Activity NADP Binding
	Biological Process	Glycine Biosynthetic Process One-carbon Metabolic Process Nucleotide Biosynthetic Process Thymidine Biosynthetic Process Tetrahydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process Oxidation-reduction Process
Pathways		Metabolism of vitamins and cofactors Defective CD320 causes methylmalonic aciduria Defective GIF causes intrinsic factor deficiency Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MMAA causes methylmalonic aciduria type cblA Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Metabolism of folate and pterines Defective TCN2 causes hereditary megaloblastic anemia Defects in cobalamin (B12) metabolism Defects in vitamin and cofactor metabolism
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: TINF2
Entrez ID		200895
HPRD ID		11246
Ensembl ID		ENSG00000178700
Uniprot IDs		Q86XF0
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein ADP-ribosylation Regulation Of Protein ADP-ribosylation Negative Regulation Of Protein Glycosylation Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Assembly Negative Regulation Of Telomere Maintenance Regulation Of Protein Glycosylation Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Glycoprotein Metabolic Process Regulation Of Telomere Maintenance Regulation Of Glycoprotein Biosynthetic Process Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Regulation Of DNA Replication Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of DNA Metabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Chromosome Organization Regulation Of Epithelial Cell Proliferation Positive Regulation Of Organelle Organization
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