PARP4

Gene Name		poly (ADP-ribose) polymerase family, member 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Spindle Microtubule Membrane Ribonucleoprotein Complex Extracellular Vesicular Exosome
	Molecular Function	DNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Enzyme Binding
	Biological Process	DNA Repair Cellular Protein Modification Process Protein ADP-ribosylation Transport Inflammatory Response Cellular Response To DNA Damage Stimulus Cell Death Response To Drug
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Sudden cardiac arrest ( 21658281)
Protein-protein Interactions		2 interactors: MVP SMAD3
Entrez ID		143
HPRD ID		09598
Ensembl ID		ENSG00000102699
Uniprot IDs		Q9UKK3
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Protein Phosphorylation Evasion Or Tolerance Of Host Defenses By Virus Negative Regulation Of Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Regulation Of Extracellular Matrix Assembly Primary MiRNA Processing Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway SMAD Protein Complex Assembly Negative Regulation Of Osteoblast Proliferation Transdifferentiation Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Catenin Import Into Nucleus Positive Regulation Of Alkaline Phosphatase Activity Negative Regulation Of Protein Autophosphorylation Paraxial Mesoderm Morphogenesis Negative Regulation Of Cellular Protein Metabolic Process Nodal Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Osteoblast Proliferation Embryonic Foregut Morphogenesis Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Adherens Junction Organization Production Of MiRNAs Involved In Gene Silencing By MiRNA Foregut Morphogenesis Modulation By Virus Of Host Morphology Or Physiology Paraxial Mesoderm Development Regulation Of Catenin Import Into Nucleus Thyroid Gland Development Osteoblast Development Positive Regulation Of Interleukin-1 Beta Production Regulation Of Protein Phosphorylation Positive Regulation Of Chondrocyte Differentiation Pericardium Development Positive Regulation Of Phosphatase Activity Positive Regulation Of Positive Chemotaxis Positive Regulation Of Interleukin-1 Production Regulation Of Protein Autophosphorylation Negative Regulation Of Signaling Signal Transduction Involved In Regulation Of Gene Expression Activin Receptor Signaling Pathway Lens Fiber Cell Differentiation Positive Regulation Of Epithelial To Mesenchymal Transition Gene Silencing By MiRNA Positive Regulation Of Bone Mineralization Cellular Response To DsRNA
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