ADH7

Gene Name		alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
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Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol
	Molecular Function	Alcohol Dehydrogenase (NAD) Activity Alcohol Dehydrogenase Activity, Zinc-dependent Aldehyde Oxidase Activity Retinol Dehydrogenase Activity Zinc Ion Binding Retinol Binding Ethanol Binding Receptor Antagonist Activity
	Biological Process	Retinoid Metabolic Process Ethanol Catabolic Process Ethanol Oxidation Xenobiotic Metabolic Process Response To Bacterium Fatty Acid Omega-oxidation Retinol Metabolic Process Retinoic Acid Metabolic Process Small Molecule Metabolic Process Response To Ethanol Oxidation-reduction Process Extracellular Negative Regulation Of Signal Transduction
Pathways		Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Ethanol oxidation Metabolic disorders of biological oxidation enzymes Defective CYP1B1 causes Glaucoma Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Phase 1 - Functionalization of compounds Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3) Biological oxidations
Drugs		NADH Nicotinamide-Adenine-Dinucleotide
Diseases
GWAS		Alcohol dependence ( 23456092) Eating disorders ( 23568457) Hypertension ( 19609347) Upper aerodigestive tract cancers ( 21437268)
Protein-protein Interactions		1 interactors: UBC
Entrez ID		131
HPRD ID		02515
Ensembl ID		ENSG00000196344
Uniprot IDs		P40394
PDB IDs		1AGN 1D1S 1D1T
Enriched GO Terms of Interacting Partners?		Viral Protein Processing Notch Receptor Processing Virion Assembly Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Glycogen Biosynthetic Process Intracellular Transport Of Virus Cellular Polysaccharide Biosynthetic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Polysaccharide Biosynthetic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint I-kappaB Kinase/NF-kappaB Signaling Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Glycogen Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Transferase Activity Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Ligase Activity Positive Regulation Of Type I Interferon Production DNA Damage Response, Signal Transduction By P53 Class Mediator Toll-like Receptor 4 Signaling Pathway Regulation Of ERBB Signaling Pathway Polysaccharide Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		1x besides bioethanol biomass capability cerevisiae dedicated ethanol fermentation furfural hemicellulosic hydrolysate industrial lignocellulosic mimicking mt8 pentose pentoses quickly saccharomyces tal tal1 tkl1 transaldolase undetoxified utilize utilizing xylose